UniProt Accession

 TFDP1_MOUSE; Q08639 

Genbank Protein ID

 X72310 

Genbank Nucleotide ID

 CAA51056.1 

Protein Name

 Transcription factor Dp-1 

Protein Synonyms/Alias

 DRTF1-polypeptide 1; E2F dimerization partner 1 

Gene Name

 Tfdp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKDASLIEA	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. 

Sequence Annotation

 DNA_BIND 113 195 Potential.
 REGION 204 277 Dimerization (Potential).
 REGION 214 246 DCB1.
 REGION 259 315 DCB2.
 MOTIF 161 195 DEF box.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 23 23 Phosphoserine; by CDK2 (Potential).  

Keyword

 Acetylation; Activator; Cell cycle; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 410 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0043276; P:anoikis; IDA:MGI.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0008544; P:epidermis development; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:2000278; P:regulation of DNA biosynthetic process; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003316; E2F_TDP.
 IPR014889; Transc_factor_DP_C.
 IPR016556; Transcription_factor_DP_subgr.
 IPR015648; Transcrpt_fac_DP.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF08781; DP
 PF02319; E2F_TDP 

SMART

  

PROSITE

  

PRINTS