CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casitas B-lineage lymphoma b 
Protein Synonyms/Alias
 E3 ubiquitin-protein ligase CBL-B 
Gene Name
 Cblb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
48ADRRTVEKTWKLMDKacetylation[1]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 938 AA 
Protein Sequence
MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120
AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE 180
FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF 240
QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV 300
TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH DHIKVTQEQY 360
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW QESDGQGCPF CRCEIKGTEP 420
IIVDPFDPRD EGSRCCSIID PFSIPMLDLD DDDDREESLM MNRLASVRKC TDRQNSPVTS 480
PGSSPLAQRR KPQPDPLQIP HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ 540
DKPLPAPPPP LRDPPPPPER PPPIPPDNRL SRHFHHGESV PSRDQPMPLE AWCPRDAFGT 600
NQVMGCRILG DGSPKPGVTA NSSLNGRHSR MGSEQVLMRK HRRHDLPSEG AKVFSNGHLA 660
TEEYDVPPRL SPPPPVTTLL PSIKCTGPLA NCLSEKTRDT VEDDDDEYKI PSSHPVSLNS 720
QPSHCHNVKA PVRSCDNGHC ILNGTHGAPS EMKKSNIPDL GIYLKGEDAF DALPPSLPPP 780
PPPARHSLIE HSKPPGSSSR PSSGQDLFLL PSDPFFDPTS GQVPLPPARR AAGDSGKANR 840
ASQDYDQLPS SSDGSQAPAR PPKPRPRRTA PEIHHRKPHG PEAALENVDA KIAKLMGEGY 900
AFEEVKRALE IAQNNVEVAR SILREFAFPP PVSPRLNL 938 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
 GO:0006955; P:immune response; IMP:MGI.
 GO:0035556; P:intracellular signal transduction; IMP:MGI.
 GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:MGI.
 GO:0045732; P:positive regulation of protein catabolic process; IMP:MGI.
 GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.
 GO:0016567; P:protein ubiquitination; IEA:GOC.
 GO:0042110; P:T cell activation; IMP:MGI. 
Interpro
 IPR024162; Adaptor_Cbl.
 IPR014741; Adaptor_Cbl_EF_hand-like.
 IPR003153; Adaptor_Cbl_N_hlx.
 IPR014742; Adaptor_Cbl_SH2-like.
 IPR024159; Cbl_PTB.
 IPR011992; EF-hand-like_dom.
 IPR000980; SH2.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02262; Cbl_N
 PF02761; Cbl_N2
 PF02762; Cbl_N3
 PF00627; UBA 
SMART
 SM00184; RING
 SM00252; SH2
 SM00165; UBA 
PROSITE
 PS51506; CBL_PTB
 PS50030; UBA
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS