| Tag | Content |
|---|
| CPLM ID | CPLM-023416 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acetyl-coenzyme A synthetase |
Protein Synonyms/Alias | Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-activating enzyme |
Gene Name | AcCoAS |
Gene Synonyms/Alias | CG9390 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 202 | DGAWRGEKPLYLKAL | acetylation | [1] | | 387 | TAIRALMKFGEGPVL | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Activates acetate so that it can be used for lipid synthesis or for energy generation. |
Sequence Annotation | |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 670 AA |
Protein Sequence | MPAEKSIYDP NPAISQNAYI SSFEEYQKFY QESLDNPAEF WSRVAKQFHW ETPADQDKFL 60
KYNFNISKGP ISIKWMEGAS TNLCYNLLDR NVRNGLGDQI AYYWEGNHPD DYSRGLTYRK 120
LLEEVCRFAN VLKDHGIRKG DRVSIYMPMI LELPIAMLAC ARIGAVHSIV FAGFSPDSLA 180
ERMFDCKAKL LITADGAWRG EKPLYLKALC DTALEKVEEM GHSVEKCIVV SHLKRVTPCQ 240
PDHVEEEIPW TDDRDYWWHE EMEDKEPACY PEWMDAEDPL FMLYTSGSTG KPKGVLHTTA 300
GYLLYAATTF KIVFDYKPGD IYWCTADVGW ITGHTYVVYG PLANGATSVI FEGTPFFPGN 360
DRYWSVIDKY KVTQFYTAPT AIRALMKFGE GPVLKHNLSG LKVLGSVGEP INPEAWLWYY 420
KYIGKEQCSI VDTFWQTETG GHVITPLPGA TPMKPGSASF PFFGVKPTLL DECGIEIKGE 480
GEGYLVFSQP WPGMMRTLYN NHERFEDTYF SKFPGYYCTG DGARRDADGY LWITGRVDDM 540
LNVSGHLMST AEVESVLTEH PRVAESAVVS RPHPVKGECL YCFITPNENE VFDQKLISDL 600
KKMVRERIGP FAMPDVIQNA PGLPKTRSGK IMRRVLRKIA VNDRNVGDTS TLADEQIVEQ 660
LFANRPVEAK 670 |
Gene Ontology | GO:0005737; C:cytoplasm; NAS:UniProtKB. GO:0003987; F:acetate-CoA ligase activity; NAS:UniProtKB. GO:0016208; F:AMP binding; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro. GO:0048149; P:behavioral response to ethanol; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |