CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037313
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Epididymis-specific alpha-mannosidase 
Protein Synonyms/Alias
  
Gene Name
 MAN2B2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
93GVASDQQKYQVRQLLubiquitination[1, 2]
181SRIDYDLKAAMQEARubiquitination[1, 2]
717SAFMEDGKSRLVLLSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 958 AA 
Protein Sequence
MGQLCWLPLL APLLLLRPPG VQSAGPIRAF VVPHSHMDVG WVYTVQESMR AYAANVYTSV 60
VEELARGQQR RFIAVEQEFF RLWWDGVASD QQKYQVRQLL EEGRLEFVIG GQVMHDEAVT 120
HLDDQILQLT EGHGFLYETF GIRPQFSWHV DPFGASATTP TLFALAGFNA HLGSRIDYDL 180
KAAMQEARGL QFVWRGSPSL SERQEIFTHI MDQYSYCTPS HIPFSNRSGF YWNGVAVFPK 240
PPQDGVYPNM SEPVTPANIN LYAELGVSVQ YATLGDYFRA LHALNVTWRV RDHHDFLPYS 300
TEPFQAWTGF YTSRSSLKGL ARRASALLYA GESMFTRYLW PAPRGHLDPT WALQQLQQLR 360
WAVSEVQHHD AITGTESPKV RDMYATHLAS GMLGMRKLMA SIVLDELQPQ APMAASSDAG 420
PAGHFASVYN PLAWTVTTIV TLTVGFPGVR VTDEAGHPVP SQIQNSTETP SAYDLLILTT 480
IPGLSYRHYN IRPTAGAQEG TQEPAATVAS TLQFGRRLRR RTSHAGRYLV PVANDCYIVL 540
LDQDTNLMHS IWERQSNRTV RVTQEFLEYH VNGDVKQGPI SDNYLFTPGK AAVPAWEAVE 600
MEIVAGQLVT EIRQYFYRNM TAQNYTYAIR SRLTHVPQGH DGELLCHRIE QEYQAGPLEL 660
NREAVLRTST NLNSQQVIYS DNNGYQMQRR PYVSYVNNSI ARNYYPMVQS AFMEDGKSRL 720
VLLSERAHGI SSQGNGQVEV MLHRRLWNNF DWDLGYNLTL NDTSVVHPVL WLLLGSWSLT 780
TALRQRSALA LQHRPVVLFG DLAGTAPKLP GPQQQEAVTL PPNLHLQILS IPGWRYSSNH 840
TEHSQNLRKG HRGEAQADLR RVLLRLYHLY EVGEDPVLSQ PVTVNLEAVL QALGSVVAVE 900
ERSLTGTWDL SMLHRWSWRT GPGRHRGDTT SPSRPPGGPI ITVHPKEIRT FFIHFQQQ 958 
Gene Ontology
 GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006013; P:mannose metabolic process; IEA:InterPro. 
Interpro
 IPR011013; Gal_mutarotase_SF_dom.
 IPR011330; Glyco_hydro/deAcase_b/a-brl.
 IPR013780; Glyco_hydro_13_b.
 IPR027291; Glyco_hydro_38/57_N.
 IPR011682; Glyco_hydro_38_C.
 IPR015341; Glyco_hydro_38_cen_dom.
 IPR000602; Glyco_hydro_38_N. 
Pfam
 PF09261; Alpha-mann_mid
 PF01074; Glyco_hydro_38
 PF07748; Glyco_hydro_38C 
SMART
 SM00872; Alpha-mann_mid 
PROSITE
  
PRINTS