| Tag | Content |
|---|
| CPLM ID | CPLM-021409 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CUB domain-containing protein 1 |
Protein Synonyms/Alias | Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD318 |
Gene Name | CDCP1 |
Gene Synonyms/Alias | TRASK; UNQ2486/PRO5773 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 109 | TTNPEVFKLEDKQPG | ubiquitination | [1] | | 367 | FTVTPDTKSKVYLRT | ubiquitination | [1] | | 600 | CSRAPTAKLATEEPP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
Sequence Annotation | DOMAIN 417 544 CUB.
MOD_RES 707 707 Phosphotyrosine.
MOD_RES 734 734 Phosphotyrosine.
CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
CARBOHYD 122 122 N-linked (GlcNAc...) (Potential).
CARBOHYD 180 180 N-linked (GlcNAc...) (Potential).
CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
CARBOHYD 270 270 N-linked (GlcNAc...) (Potential).
CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
DISULFID 476 499 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 836 AA |
Protein Sequence | MQEGVKMALH LPWFHPRNVS GFSIANRSSI KRLCIIESVF EGEGSATLMS ANYPEGFPED 60
ELMTWQFVVP AHLRASVSFL NFNLSNCERK EERVEYYIPG STTNPEVFKL EDKQPGNMAG 120
NFNLSLQGCD QDAQSPGILR LQFQVLVQHP QNESNKIYVV DLSNERAMSL TIEPRPVKQS 180
RKFVPGCFVC LESRTCSSNL TLTSGSKHKI SFLCDDLTRL WMNVEKTISC TDHRYCQRKS 240
YSLQVPSDIL HLPVELHDFS WKLLVPKDRL SLVLVPAQKL QQHTHEKPCN TSFSYLVASA 300
IPSQDLYFGS FCPGGSIKQI QVKQNISVTL RTFAPSFQQE ASRQGLTVSF IPYFKEEGVF 360
TVTPDTKSKV YLRTPNWDRG LPSLTSVSWN ISVPRDQVAC LTFFKERSGV VCQTGRAFMI 420
IQEQRTRAEE IFSLDEDVLP KPSFHHHSFW VNISNCSPTS GKQLDLLFSV TLTPRTVDLT 480
VILIAAVGGG VLLLSALGLI ICCVKKKKKK TNKGPAVGIY NDNINTEMPR QPKKFQKGRK 540
DNDSHVYAVI EDTMVYGHLL QDSSGSFLQP EVDTYRPFQG TMGVCPPSPP TICSRAPTAK 600
LATEEPPPRS PPESESEPYT FSHPNNGDVS SKDTDIPLLN TQEPMEPAE 649 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |