UniProt Accession

 ST1B1_RAT; P52847 

Genbank Protein ID

 U38419; D89375 

Genbank Nucleotide ID

 AAC52387.1; BAA24546.1 

Protein Name

 Sulfotransferase family cytosolic 1B member 1 

Protein Synonyms/Alias

 ST1B1; Sulfotransferase 1B1; DOPA/tyrosine sulfotransferase 

Gene Name

 Sult1b1 

Gene Synonyms/Alias

 St1b1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
98	RSGVELLKKTPSPRI	acetylation	[1]
107	TPSPRIIKTHLPIDL	acetylation	[1]
117	LPIDLLPKSFWDNKC	acetylation	[1]
183	HVKSWWEKREGHPIL	acetylation	[1]
214	KIANFLDKTLDEHTL	acetylation	[1]
276	FTMTQSEKFDAIYKK	acetylation	[1]
282	EKFDAIYKKKLSGTT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. sulfonation of DOPA, tyrosine isomers and thyroid hormones such as 3,3',5-triiodothyronine and 3,3'-diiodothyronine. May play a role in the limitation of the production of L-DOPA and L-m-tyrosine and also in facilitating their excretion. 

Sequence Annotation

 NP_BIND 48 53 PAPS (By similarity).
 NP_BIND 228 233 PAPS (By similarity).
 NP_BIND 258 260 PAPS (By similarity).
 ACT_SITE 109 109 Proton acceptor (By similarity).
 BINDING 131 131 PAPS (By similarity).
 BINDING 139 139 PAPS (By similarity).
 BINDING 194 194 PAPS (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:RGD.
 GO:0004062; F:aryl sulfotransferase activity; IDA:RGD.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
 GO:0051923; P:sulfation; IEA:Compara.
 GO:0042403; P:thyroid hormone metabolic process; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS