CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039275
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Tjp1 
Protein Synonyms/Alias
 Tight junction protein 1 (Predicted) 
Gene Name
 Tjp1 
Gene Synonyms/Alias
 Tjp1_predicted; rCG_24681 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
345GAVSTPVKHVDDHTPacetylation[1]
1515AYNRFTPKPYTSSARacetylation[1]
1584TFSVHTDKPKYQINNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1733 AA 
Protein Sequence
MEETAIWEQH TVTLHRAPGF GFGIAISGGR DNPHFQSGET SIVISDVLKG GPAEGQLQEN 60
DRVAMVNGVS MDNVEHAFAV QQLRKSGKNA KITIRRKKKV QIPVSHPDPD PVSDNEDDSY 120
DEDVHDPRSG RGALANRRGE KSWARDRSAS RDRSLSPRSD RRSVASSQPA KPTKVTLVKS 180
RKNEEYGLRL ASHIFVKEIS QDSLAARDGN IQEGDVVLKI NGTVTENMSL TDAKTLIERS 240
KGKLKMVVQR DERATLLNVP DLSDSIHSAN ASERDDISEI QSLASDHSVR SHDRPPRRSQ 300
SRSPDQRSEP SDHSTQSPQQ PSNGSLRSRE EERMSKPGAV STPVKHVDDH TPKAVEEVTV 360
EKHEKQTPTL PEPKPVYAQV GQPDVDLPVS PSDGVLPNST HEDGILRPSM KLVKFRKGDS 420
VGLRLAGGND VGIFVAGVLE DSPAAKEGLE EGDQILRVNN VDFTNIIREE AVLFLLDLPK 480
GEEVTILAQK KKDVYRRIVE SDVGDSFYIR THFEYEKESP YGLSFNKGEV FRVVDTLYNG 540
KLGSWLAIRI GKNHKEVERG IVPNKNRAEQ LASVQYTLPK TAGGDRADFW RFRGLRSSKR 600
NLRKSREDLS AQPVQTKFPA YERVVLREAG FLRPVTIFGP IADVAREKLA REEPDIYQIA 660
KSEPRDAGTD HRSSGIIRLH TIKQIIDQDK HALLDVTPNA VDRLNYAQWY PIVVFLNPDS 720
KQGVKTMRMR LCPESRKSAR KLYERSHKLR KNNHHLFTTT INLNSMNDGW YGALKEAIQQ 780
QQNQLVWVSE GKADGATSDD LDLHDDRLSY LSAPGSEYSM YSTDSRHTSD YEDTDTEGGA 840
YTDQELDETL NDEVGTPPES AITRSSEPVR EDSSGMHHEN QTYPPYSPQA QPQAIHRIDS 900
PGLKTASQQK AEASSPVPYL SPETNPASSA SAVKHNVNLT NVNLEEPTPA PPTSHVSQAD 960
CLGAPSPEAP HTMLRDEGVS LPSHVDPAKV YRKEPYPEEM MRQNHILKQP ALGHPGQRLD 1020
KEPNPAYDPQ LPYVEKQASR DLEQPPYRYE SSSYTDQFSR NYDHRLRFED RVPTYEDQWS 1080
YYDDKQPYPT RPFDTQHPRD LDSRQHPEEA SERGYFQRFE EPAPLPYDSR PRYEQLPRTS 1140
TLRHEEQPTS GYEVHNRYRP EAQPYAPAGP KSSEPKQYFD QYPRSYEQVP PPGFTSKTGH 1200
YEPLHGAAVV PPLIPSSQHK PEVLPSATKP QPPPPALTEE EEDPAMKPQS VLTRVKMFEN 1260
KRSASLENKK DVNDTASFKP PEVASKPPSA SLVGPKPVSQ TQFSEHDKTL YRLPEPQKPQ 1320
AKPPEDIVRS NHYDPEEDEE YYRKQLSYFD RRSFESKPPA HIPAGHHSEP AKPVHSQSQP 1380
NFSSYSSKGK PETDAMDRSF SEKRYDPTQA MPPPPPLPSQ YSQPVPPLSN SSLHIHSKAA 1440
QSEGNSVSLD FQNSYISKPD PPPSQSKPAT FRPPTREDPP QTFYPQKSFP DKASVNGAEQ 1500
TQKTITPAYN RFTPKPYTSS ARPFERKFES PKFNHNLLPS ETVHKPELSS KPPPSPKTLM 1560
KAHSSTQPPE FDSGVETFSV HTDKPKYQIN NISTMPKAVP VSPSAVEEDE DEDGHTVVAT 1620
ARGIFNSNGG VLSSIETGVS IIIPQGAIPE GIEQEIYFKV CRDNSILPPL DKEKGETLLS 1680
PLVMCGPHGL KFLKPVELRL PHCDPKTWQN KCLPGDPNYL VGANCVSVLI DHF 1733 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0016327; C:apicolateral plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0046581; C:intercellular canaliculus; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005923; C:tight junction; IDA:RGD.
 GO:0001825; P:blastocyst formation; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0043116; P:negative regulation of vascular permeability; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0071000; P:response to magnetism; IEP:RGD. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR005417; ZonOcculdens.
 IPR005418; ZonOcculS1.
 IPR000906; ZU5. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2
 PF00791; ZU5 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3
 SM00218; ZU5 
PROSITE
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3
 PS51145; ZU5 
PRINTS
 PR01597; ZONOCCLUDNS.
 PR01598; ZONOCCLUDNS1.