CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027874
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Multidrug resistance protein 1a 
Protein Synonyms/Alias
 Protein Abcb1a; RCG41085 
Gene Name
 Abcb1a 
Gene Synonyms/Alias
 Pgy1; rCG_41085 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1091GTVFLDGKEIKQLNVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1272 AA 
Protein Sequence
MELEEDLNGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRFYM LLGTLAAIIH 60
GIALPLMMLV FGDMTDSFAN VGNNRSMSFY NATDIYAKLE DEMTTYAYYY TGIGAGVLIV 120
AYIQVSLWCL AAGRQIHKIR QKFFHAIMNQ EIGWFDVHDV GELNTRLTDD VSKINEGIGD 180
KIGMFFQAMA TFFGGFIIGF TRGWKLTLVI LAISPVLGLS AGIWAKILSS FTDKELQAYA 240
KAGAVAEEVL AAIRTVIAFG GQKKELERYN NNLEEAKRLG IKKAITANIS MGAAFLLIYA 300
SYALAFWYGT SLVISKEYTI GQVLTVFFSV LIGAFSVGQA SPNIEAFANA RGAAYEVFSI 360
IDNKPSIDSF SKSGHKPDNI QGNLEFKNIH FSYPSRKDVQ ILKGLNLKVK SGQTVALVGN 420
SGCGKSTTVQ LLQRLYDPIE GEVSIDGQDI RTINVRYLRE IIGVVSQEPV LFATTIAENI 480
RYGRENVTMD EIEKAVKEAN AYDFIMKLPH KFDTLVGERG AQLSGGQKQR IAIARALVRN 540
PKILLLDEAT SALDTESEAV VQAALDKARE GRTTIVIAHR LSTVRNADVI AGFDGGVIVE 600
QGNHDELMRE KGIYFKLVMT QTAGNEIELG NEACESKDGI DNVDMSSKDS GSSLIRRRST 660
RKSIRGPHDQ DGELSTKEAL DDDVPPASFW RILKLNSTEW PYFVVGVFCA IINGGLQPAF 720
SIIFSKVVGV FTKNDTPEIQ RQNSNLFSLL FLILGIISFI TFFLQGFTFG KAGEILTKRL 780
RYMVFKSMLR QDISWFDDPK NTTGALTTRL ANDAAQVKGA TGSRLAVITQ NIANLGTGII 840
ISLIYGWQLT LLLLAIVPII AIAGVVEMKM LSGQALKDKK ELEGSGKIAT EAIENFRTVV 900
SLTREQKFET MYAQSLQIPY RNALKKAHVF GITFSFTQAM MYFSYAACFR FGAYLVAREL 960
MTFENVLLVF SAIVFGAMAV GQVSSFAPDY AKAKVSASHI IRIIEKIPEI DSYSTEGLKP 1020
NMLEGNVKFN GVMFNYPTRP NIPVLQGLSL EVKKGQTLAL VGSSGCGKST VVQLLERFYD 1080
PMAGTVFLDG KEIKQLNVQW LRAHLGIVSQ EPILFDCSIA ENIAYGDNSR VVSHEEIVKA 1140
AKEANIHQFI DSLPEKYNTR VGDKGTQLSG GQKQRIAIAR ALVRQPHILL LDEATSALDT 1200
ESEKVVQEAL DKAREGRTCI VIAHRLSTIQ NADLIVVIQN GQVKEHGTHQ QLLAQKGIYF 1260
SMVSVQAGAK RS 1272 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IBA:RefGenome.
 GO:0000139; C:Golgi membrane; IBA:RefGenome.
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0046581; C:intercellular canaliculus; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome.
 GO:0007623; P:circadian rhythm; IEP:RGD.
 GO:0006855; P:drug transmembrane transport; IDA:RGD.
 GO:0007595; P:lactation; IEP:RGD.
 GO:0060548; P:negative regulation of cell death; IMP:RGD.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0033280; P:response to vitamin D; IEP:RGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS