CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000317
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gem-associated protein 2 
Protein Synonyms/Alias
 Gemin-2; Component of gems 2; Survival of motor neuron protein-interacting protein 1; SMN-interacting protein 1 
Gene Name
 GEMIN2 
Gene Synonyms/Alias
 SIP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75VAQIDPKKLKRKQSVubiquitination[1]
125NKHRSHWKSQQLDSNubiquitination[1]
145SEDEEGWKKFCLGEKubiquitination[1]
146EDEEGWKKFCLGEKLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. 
Sequence Annotation
 MOD_RES 166 166 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ EYLRRVQIEA 60
AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL QWQQQQVAQF STVRQNVNKH 120
RSHWKSQQLD SNVTMPKSED EEGWKKFCLG EKLCADGAVG PATNESPGID YVQIGFPPLL 180
SIVSRMNQAT VTSVLEYLSN WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR 240
CSEVRLLVDS KDDERVPALN LLICLVSRYF DQRDLADEPS 280 
Gene Ontology
 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005681; C:spliceosomal complex; TAS:ProtInc.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000245; P:spliceosomal complex assembly; TAS:ProtInc.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome. 
Interpro
 IPR007022; SIP1.
 IPR017364; Survival_motor_neuron_Gemin2. 
Pfam
  
SMART
  
PROSITE
  
PRINTS