UniProt Accession

 ACADL_HUMAN; P28330; B2R8T3; Q8IUN8 

Genbank Protein ID

 M74096; AK313498; AC006994; CH471063; BC039063; BC064549 

Genbank Nucleotide ID

 AAA51565.1; BAG36280.1; AAY14881.1; EAW70481.1; AAH39063.1; AAH64549.1 

Protein Name

 Long-chain specific acyl-CoA dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 LCAD 

Gene Name

 ACADL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	RLETPSAKKLTDIGI	acetylation	[1]
156	GSEEQIKHFIPQMTA	acetylation	[1]
189	QGIKTNAKKDGSDWI	acetylation	[1, 2]
240	FLVENGMKGFIKGRK	acetylation	[1]
254	KLHKMGLKAQDTAEL	acetylation	[1]
318	RNYVKQRKAFGKTVA	acetylation	[1]
322	KQRKAFGKTVAHLQT	acetylation	[1]
358	CLQLHEAKRLDSATA	acetylation	[1]

Reference

 [1] SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E.
 Nature. 2010 Mar 4;464(7285):121-5. [PMID: 20203611]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0004466; F:long-chain-acyl-CoA dehydrogenase activity; ISS:BHF-UCL.
 GO:0016401; F:palmitoyl-CoA oxidase activity; ISS:BHF-UCL.
 GO:0042413; P:carnitine catabolic process; ISS:BHF-UCL.
 GO:0019254; P:carnitine metabolic process, CoA-linked; ISS:BHF-UCL.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; ISS:BHF-UCL.
 GO:0042758; P:long-chain fatty acid catabolic process; IEA:Compara.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:BHF-UCL.
 GO:0046322; P:negative regulation of fatty acid oxidation; ISS:BHF-UCL.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0090181; P:regulation of cholesterol metabolic process; ISS:BHF-UCL.
 GO:0001659; P:temperature homeostasis; ISS:BHF-UCL. 

Interpro

 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 

Pfam

 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 

SMART

  

PROSITE

 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 

PRINTS