UniProt Accession

 EF1A2_RAT; P62632; P27706 

Genbank Protein ID

 M62751; M62752; BC074016 

Genbank Nucleotide ID

 AAA41966.1; AAA41967.1; AAH74016.1 

Protein Name

 Elongation factor 1-alpha 2 

Protein Synonyms/Alias

 EF-1-alpha-2; Eukaryotic elongation factor 1 A-2; eEF1A-2; Statin-S1 

Gene Name

 Eef1a2 

Gene Synonyms/Alias

 Eef1al; Stn; Stnl 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
165	TEPAYSEKRYDEIVK	acetylation	[1]
172	KRYDEIVKEVSAYIK	acetylation	[1]
179	KEVSAYIKKIGYNPA	acetylation	[1]
215	MPWFKGWKVERKEGN	acetylation	[1]
439	TVAVGVIKNVEKKSG	acetylation	[1]
450	KKSGGAGKVTKSAQK	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. 

Sequence Annotation

 NP_BIND 14 21 GTP (By similarity).
 NP_BIND 91 95 GTP (By similarity).
 NP_BIND 153 156 GTP (By similarity).
 MOD_RES 29 29 Phosphotyrosine (By similarity).
 MOD_RES 55 55 N6,N6,N6-trimethyllysine (By similarity).
 MOD_RES 141 141 Phosphotyrosine (By similarity).
 MOD_RES 165 165 N6,N6,N6-trimethyllysine (By similarity).
 MOD_RES 179 179 N6-acetyllysine (By similarity).
 MOD_RES 301 301 5-glutamyl glycerylphosphorylethanolamine
 MOD_RES 374 374 5-glutamyl glycerylphosphorylethanolamine
 MOD_RES 439 439 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0010035; P:response to inorganic substance; IEP:RGD. 

Interpro

 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 

Pfam

 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 

SMART

  

PROSITE

 PS00301; EFACTOR_GTP 

PRINTS

 PR00315; ELONGATNFCT.