CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Syndecan-2 
Protein Synonyms/Alias
 SYND2; Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD362 
Gene Name
 SDC2 
Gene Synonyms/Alias
 HSPG1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185SYDLGERKPSSAAYQubiquitination[1]
193PSSAAYQKAPTKEFYubiquitination[1, 2, 3, 4]
197AYQKAPTKEFYA***ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). 
Sequence Annotation
 MOD_RES 187 187 Phosphoserine.
 CARBOHYD 41 41 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 55 55 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 57 57 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 101 101 O-linked (GalNAc...).  
Keyword
 Complete proteome; Differentiation; Glycoprotein; Heparan sulfate; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Proteoglycan; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 201 AA 
Protein Sequence
MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD 60
EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK 120
MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD 180
LGERKPSSAA YQKAPTKEFY A 201 
Gene Ontology
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030204; P:chondroitin sulfate metabolic process; TAS:Reactome.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
 GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.
 GO:0031000; P:response to caffeine; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR003585; Neurexin-like.
 IPR001050; Syndecan. 
Pfam
 PF01034; Syndecan 
SMART
 SM00294; 4.1m 
PROSITE
 PS00964; SYNDECAN 
PRINTS