CPLM-022099

Genbank Nucleotide ID

Serine incorporator 1

Protein Synonyms/Alias

Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2

KIAA1253; TDE1L; TDE2; UNQ396/PRO732

Homo sapiens (Human)

Position	Peptide	Type	References
343	SNNSQVNKLTLTSDE	ubiquitination	[1, 2, 3, 4, 5, 6, 7, 8]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
[5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity).

MOD_RES 351 351 Phosphoserine.
MOD_RES 352 352 Phosphothreonine.
MOD_RES 361 361 Phosphoserine.
MOD_RES 364 364 Phosphoserine.
LIPID 2 2 N-myristoyl glycine.
CARBOHYD 298 298 N-linked (GlcNAc...).

Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lipoprotein; Membrane; Myristate; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005789; C:endoplasmic reticulum membrane; ISS:HGNC.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; ISS:HGNC.
GO:0015194; F:L-serine transmembrane transporter activity; ISS:HGNC.
GO:0006658; P:phosphatidylserine metabolic process; ISS:HGNC.
GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
GO:0051347; P:positive regulation of transferase activity; ISS:HGNC.
GO:0006665; P:sphingolipid metabolic process; ISS:HGNC.