CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000860
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AF4/FMR2 family member 2 
Protein Synonyms/Alias
 FMR2P; Fragile X mental retardation protein 2 homolog; Protein FMR-2; Protein Ox19 
Gene Name
 Aff2 
Gene Synonyms/Alias
 Fmr2; Ox19 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
594SQRTIGKKQPKKVEKacetylation[1]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
 RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. 
Sequence Annotation
 MOD_RES 395 395 Phosphoserine (By similarity).
 MOD_RES 396 396 Phosphoserine (By similarity).
 MOD_RES 482 482 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1272 AA 
Protein Sequence
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE EDLFSSGFDL FGEPYKVAEY 60
TNKGDALANR VQNTLGSYDE MKDLLSNHSS QNHLVGIPKN SAPQTPISKS EASFYPEQKN 120
RMIPSHQETT HSSTPMPPPS VVILNSTLIH SNRKSKSEWP RDSHNTSPAQ ASQTSSQPNK 180
MQTSTQDPPQ TRLEDFFVYP AEQPQIGTVE KSNPSSKEEN NPNSGGEDTF KEIFQSNSPE 240
ESEFTVQAPG SPLVASSLLA PSSGLSVPTF PPGLYCKTSM GQQKPTAYVR PMDGQDQATD 300
ISPTLKPSIE FENSFGNLSF GSLLDGKPSA VSSKTKLPKF TILQTSEVSL TSDPSCVEEI 360
LRESQHLTPG FTLQKWSDPS SRASTKMLED DLKLSSDEDD LEPVKTLTTQ CTANELYQAV 420
EKAKPKNNPV NPLLATPQST PATQTNVGSG SSSESESSSE SDSDTESSTT DSESNEAPRV 480
ATPEPEPPST NKWQLDKWLN KVTSQNKSFI CGQNETPTET ISLPPPIIQP VEVQVKVKPN 540
PSQAVAVPKE RPLLSLIREK ARPRPTQKTP ETKALKHKLS TSVDTVSQRT IGKKQPKKVE 600
KNTSFEEFTW PKPNITNSTP KEKGSVELPD PPRSRNKATA HKPVPRKEPR PHVPLATEKK 660
KYRGPGKIVP KSREFIETDS STSDSNTDQE ETLQIKVLPP CITSKSKETS NASLTLSTLT 720
NGNSNNLSTS NEETAFSPPP AMQTELLSPL RDHENPKNLW VKIDLDLLSR VPGQNSVPVT 780
PAKTDYKETA SKPKRQTAAT AVEKPAPKGK RKHKPAETAE KIPEKKQRLE DNTTICLLPP 840
CISPAPPHKP PSTRENSSRR ANRKKEEKLF PPALSPLAED PPRRRNVSGN NGHFGQDKNI 900
SMAGQITSSK PKRSEGKFCA TFKGISINEG DAPKKAASAT VTVANMALAT ATATATVPAI 960
VTATVTATAT TTATATTTTT TTTISSITPT ITSGLMDSSH LEMTSWAALP LLSSSSANVR 1020
RPKLTFDDSV HNADFYMQEA KKLKHKADAL FEKFGKAVNY ADAALSFTEC GNAMERDPLE 1080
AKSPYTMYSE TVELLRYAMR LKNFASPLAS DGDKKLAVLC YRCLSLLYLR MFKLKKDHAM 1140
KYSRSLMEYF KQNASKVTQI PSPWVGNGKN TPSPVSLNNV SPINSVGNCN NGPVTIPQRI 1200
HHMAASHVNI TSNVLRGYEH WDMADKLTRD NKEFFGDLDT LMGPLTQHSS MTNLVRYVRQ 1260
GLCWLRIDAH LL 1272 
Gene Ontology
 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0002151; F:G-quadruplex RNA binding; IDA:UniProtKB.
 GO:0007611; P:learning or memory; IMP:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043484; P:regulation of RNA splicing; IDA:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR007797; TF_AF4/FMR2. 
Pfam
 PF05110; AF-4 
SMART
  
PROSITE
  
PRINTS