CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015467
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin-binding protein 
Protein Synonyms/Alias
 Scaffold protein Tuba 
Gene Name
 DNMBP 
Gene Synonyms/Alias
 KIAA1010 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
286GWLEGSLKGRTGIFPubiquitination[1, 2]
561QQLIEFEKSLAGPGTubiquitination[1, 2]
594DIVRGSSKLITEQELubiquitination[1]
722LNLMLEEKQDESSRAubiquitination[2]
1009NRVSSHLKHLTGFAPubiquitination[2]
1019TGFAPQIKDEVFEETubiquitination[1, 2]
1028EVFEETEKNFRMQERubiquitination[2]
1096DQLFTNFKERTERLVubiquitination[1, 2]
1246PESLPATKKPFERKTubiquitination[2]
1247ESLPATKKPFERKTIubiquitination[2]
1261IDRQSARKPLLGLPSubiquitination[1, 2]
1288LARYPPEKLFQAERNubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Scaffold protein that links dynamin with actin- regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). 
Sequence Annotation
 DOMAIN 2 61 SH3 1.
 DOMAIN 66 126 SH3 2.
 DOMAIN 145 204 SH3 3.
 DOMAIN 243 302 SH3 4.
 DOMAIN 784 967 DH.
 DOMAIN 1008 1217 BAR.
 DOMAIN 1285 1348 SH3 5.
 DOMAIN 1513 1576 SH3 6.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Polymorphism; Reference proteome; Repeat; SH3 domain; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1577 AA 
Protein Sequence
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ FPSSFVEIVT 60
IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT AGWLQGRSCW GARGFFPSSC 120
VRELCLSSQS RQWHSQSALF QIPEYSMGQA RALMGLSAQL DEELDFREGD VITIIGVPEP 180
GWFEGELEGR RGIFPEGFVE LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED 240
EEEPGTYGVA LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC 300
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD CIISEAPTSP 360
LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS PTSDPTEVVN GISSQPQVPF 420
HPNLQKSQYY STVGGSHPHS EQYPDLLPLE ARTRDYASLP PKRMYSQLKT LQKPVLPLYR 480
GSSVSASRVV KPRQSSPQLH NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS 540
QGDGSTDLDS KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE 600
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS AQQRTNAVSP 660
KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE MERDLDMYSR AQEELNLMLE 720
EKQDESSRAE TLEDLKFCES NIESLNMELQ QLREMTLLSS QSSSLVAPSG SVSAENPEQR 780
MLEKRAKVIE ELLQTERDYI RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ 840
LLAALEISDA VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL 900
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL TNAVLAVKEI 960
NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK SNRVSSHLKH LTGFAPQIKD 1020
EVFEETEKNF RMQERLIKSF IRDLSLYLQH IRESACVKVV AAVSMWDVCM ERGHRDLEQF 1080
ERVHRYISDQ LFTNFKERTE RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK 1140
LKDKKTLEEL QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ 1200
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE RKTIDRQSAR 1260
KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ DLDVSLLEGD LVGVIKKKDP 1320
MGSQNRWLID NGVTKGFVYS SFLKPYNPRR SHSDASVGSH SSTESEHGSS SPRFPRQNSG 1380
STLTFNPSSM AVSFTSGSCQ KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS 1440
TSQPRSGDSA DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP 1500
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG NTEWWLAEVN 1560
GKKGYVPSNY IRKTEYT 1577 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR000108; p67phox.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF03114; BAR
 PF00621; RhoGEF
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00721; BAR
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS51021; BAR
 PS00741; DH_1
 PS50010; DH_2
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.