CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024025
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sulfide:quinone oxidoreductase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 SQRDL 
Gene Synonyms/Alias
 CGI-44 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115PSGVEWIKARVTELNubiquitination[1]
135IHTDDDEKISYRYLIacetylation[2]
155QLDYEKIKGLPEGFAubiquitination[1]
173IGSNYSVKTVEKTWKacetylation[2]
173IGSNYSVKTVEKTWKubiquitination[1, 3]
180KTVEKTWKALQDFKEacetylation[2]
186WKALQDFKEGNAIFTubiquitination[1]
320AGWVDVDKETLQHRRacetylation[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MVPLVAVVSG PRAQLFACLL RLGTQQVGPL QLHTGASHAA RNHYEVLVLG GGSGGITMAA 60
RMKRKVGAEN VAIVEPSERH FYQPIWTLVG AGAKQLSSSG RPTASVIPSG VEWIKARVTE 120
LNPDKNCIHT DDDEKISYRY LIIALGIQLD YEKIKGLPEG FAHPKIGSNY SVKTVEKTWK 180
ALQDFKEGNA IFTFPNTPVK CAGAPQKIMY LSEAYFRKTG KRSKANIIFN TSLGAIFGVK 240
KYADALQEII QERNLTVNYK KNLIEVRADK QEAVFENLDK PGETQVISYE MLHVTPPMSP 300
PDVLKTSPVA DAAGWVDVDK ETLQHRRYPN VFGIGDCTNL PTSKTAAAVA AQSGILDRTI 360
SVIMKNQTPT KKYDGYTSCP LVTGYNRVIL AEFDYKAEPL ETFPFDQSKE RLSMYLMKAD 420
LMPFLYWNMM LRGYWGGPAF LRKLFHLGMS 450 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0070224; F:sulfide:quinone oxidoreductase activity; TAS:Reactome.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0070221; P:sulfide oxidation, using sulfide:quinone oxidoreductase; TAS:Reactome.
 GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome. 
Interpro
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR015904; Sulphide_quinone_reductase. 
Pfam
 PF07992; Pyr_redox_2 
SMART
  
PROSITE
  
PRINTS