UniProt Accession

 SKAP2_HUMAN; O75563; A4D173; Q53GP6; Q75MK6; Q75MZ4; Q9UBZ3; Q9UED8 

Genbank Protein ID

 AB014486; AJ004886; AF072166; AF051323; AK313209; AK222885; AC003999; AC011299; CH236948; CH471073; BC002893; BC036044 

Genbank Nucleotide ID

 BAA36194.1; CAA06193.1; AAC39924.1; AAC99296.1; BAG36025.1; BAD96605.1; AAS02033.1; AAS07536.1; EAL24231.1; EAW93859.1; AAH02893.1; AAH36044.1 

Protein Name

 Src kinase-associated phosphoprotein 2 

Protein Synonyms/Alias

 Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP55 homolog; SKAP-55HOM; SKAP-HOM; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains 

Gene Name

 SKAP2 

Gene Synonyms/Alias

 PRAP; RA70; SAPS; SCAP2; SKAP55R 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	YLQEFQDKGDAEDGE	ubiquitination	[1]
119	QDLPFVLKAGYLEKR	ubiquitination	[1]
125	LKAGYLEKRRKDHSF	ubiquitination	[1]
205	QFTAASPKDAEEWVQ	ubiquitination	[1, 2]
275	EEDSAPVKVEEQRKM	ubiquitination	[2]
281	VKVEEQRKMSQDSVH	ubiquitination	[1]
329	DVIYILSKEYNRYGW	ubiquitination	[1, 2]
342	GWWVGEMKGAIGLVP	ubiquitination	[2]
350	GAIGLVPKAYIMEMY	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. 

Sequence Annotation

 DOMAIN 116 219 PH.
 DOMAIN 297 358 SH3.
 REGION 14 64 Homodimerization (By similarity).
 MOD_RES 75 75 Phosphotyrosine.
 MOD_RES 151 151 Phosphotyrosine (By similarity).
 MOD_RES 197 197 Phosphotyrosine (By similarity).
 MOD_RES 261 261 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; B-cell activation; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain. 

Pfam

 PF00169; PH
 PF00018; SH3_1 

SMART

 SM00233; PH
 SM00326; SH3 

PROSITE

 PS50003; PH_DOMAIN
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.