UniProt Accession

 GOSR1_HUMAN; O95249; J3KST5; O75392 

Genbank Protein ID

 AF047438; AF073926; AC006050; AC011840; CH471159; BC040471 

Genbank Nucleotide ID

 AAC39889.1; AAD12945.1; EAW51229.1; AAH40471.1 

Protein Name

 Golgi SNAP receptor complex member 1 

Protein Synonyms/Alias

 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28 

Gene Name

 GOSR1 

Gene Synonyms/Alias

 GS28 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
124	DYTHEFHKTKANFMA	acetylation	[1]
144	NLMGSVRKDIESYKS	ubiquitination	[2]
150	RKDIESYKSGSGVNN	ubiquitination	[3, 4]
165	RRTELFLKEHDHLRN	ubiquitination	[2, 5, 6]
188	ISIAMATKENMTSQR	ubiquitination	[3, 4]
204	MLKSIHSKMNTLANR	ubiquitination	[3, 5, 6]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. 

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; ER-Golgi transport; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0000139; C:Golgi membrane; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; TAS:HGNC.
 GO:0005484; F:SNAP receptor activity; IDA:HGNC.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0006891; P:intra-Golgi vesicle-mediated transport; TAS:ProtInc.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042147; P:retrograde transport, endosome to Golgi; IDA:HGNC. 

Interpro

 IPR023601; Golgi_SNAP_su1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS