UniProt Accession

 DESI1_MOUSE; Q9CQT7; Q3V2M9 

Genbank Protein ID

 AK005706; AK005963; AK131703; AK146155; BC056972; BC071205; BC131979; BC132642 

Genbank Nucleotide ID

 BAB24198.1; BAB24342.1; BAE20768.1; BAE26939.1; AAH56972.1; AAH71205.1; AAI31980.1; AAI32643.1 

Protein Name

 Desumoylating isopeptidase 1 

Protein Synonyms/Alias

 DeSI-1; PPPDE peptidase domain-containing protein 2; Protein FAM152B 

Gene Name

 Desi1 

Gene Synonyms/Alias

 D15Wsu75e; Fam152b; Pppde2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	LYVYDLSKGLARRLS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. 

Sequence Annotation

 DOMAIN 7 149 PPPDE peptidase.
 ACT_SITE 38 38
 ACT_SITE 108 108  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR008580; DUF862_euk. 

Pfam

 PF05903; DUF862 

SMART

  

PROSITE

  

PRINTS