| Tag | Content |
|---|
| CPLM ID | CPLM-018830 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Type II iodothyronine deiodinase |
Protein Synonyms/Alias | 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase |
Gene Name | DIO2 |
Gene Synonyms/Alias | ITDI2; TXDI2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 65 | EGLRCVWKSFLLDAY | ubiquitination | [1] |
|
Reference | [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR. J Biol Chem. 2011 Dec 2;286(48):41530-8. [ PMID: 21987572] |
Functional Description | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
Sequence Annotation | ACT_SITE 133 133 |
Keyword | Alternative splicing; Complete proteome; Membrane; Oxidoreductase; Polymorphism; Reference proteome; Selenocysteine; Thyroid hormones biosynthesis; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 273 AA |
Protein Sequence | MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL 60
RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP 120
ERPLVVNFGS ATUPPFTSQL PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF 180
EVKKHQNQED RCAAAQQLLE RFSLPPQCRV VADRMDNNAN IAYGVAFERV CIVQRQKIAY 240
LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG 273 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0008430; F:selenium binding; IC:UniProtKB. GO:0004800; F:thyroxine 5'-deiodinase activity; IDA:UniProtKB. GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome. GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW. GO:0001514; P:selenocysteine incorporation; NAS:UniProtKB. GO:0006590; P:thyroid hormone generation; TAS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |