| Tag | Content |
|---|
| CPLM ID | CPLM-009177 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 4 |
Protein Synonyms/Alias | |
Gene Name | Dock4 |
Gene Synonyms/Alias | Kiaa0716 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 165 | GLDLVPRKEYAMVDP | ubiquitination | [1] | | 605 | TGCLSKLKEIDGSEI | ubiquitination | [1] | | 814 | IKLQCIGKTVESQLY | ubiquitination | [1] | | 1204 | FYKTELNKEEMYIRY | ubiquitination | [1] | | 1536 | YQEAFFVKDYILSHP | ubiquitination | [1] | | 1583 | QDMRPLHKKLVDQFF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP (By similarity). |
Sequence Annotation | DOMAIN 6 67 SH3.
DOMAIN 401 574 DHR-1.
DOMAIN 1199 1605 DHR-2.
MOTIF 1797 1803 SH3-binding (Potential).
MOD_RES 167 167 Phosphotyrosine.
MOD_RES 1623 1623 Phosphoserine (By similarity).
MOD_RES 1627 1627 Phosphoserine (By similarity).
MOD_RES 1629 1629 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; SH3 domain; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1978 AA |
Protein Sequence | MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 60
YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 120
EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 180
YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 240
LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
FGCAVLSIAD LLTGETKDDL VLKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 360
LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSDIIMPGEM RNDLYITVER GEFEKGGKSV 420
ARNVEVTMFI VDSNGQPLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 480
RGSHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 540
RYLKLPFSKV IFLGNNNQTM KATKESFWIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 660
MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 720
LATGGQNEEE FRCCIQELLM SVRFFLSQES KGTGALSQSQ AVFLSSFPAV YSELLKLFDV 780
REVANLVQDT LGSLPTIMHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 840
HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQAS 900
SSAMRLQFQD VTGEFVACLL SLLRQMTDRH YQQLLNSFST KEELRDFLLQ IFTVFRILIR 960
PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 1020
QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 1080
LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP 1140
YPSLLKKIER ETWRESGVSL IATVTRLMER LLDYRDCMKI GEVDGKKIGC TVSLLNFYKT 1200
ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL TYPMQTEWQR 1260
KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN LSKMRMMEAS LYDKIMDQQR 1320
LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD YERLEAFQQR MLNEFPHAIA MQHANQPDET 1380
IFQAEAQYLQ IYAVTPIPES QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGAKDKEN 1440
EFKSLWVERT SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 1500
TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKDYIL SHPEDGEKIA RLRELMLEQA 1560
QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSFGIQE FPACIQASPV HFPNGSPRVC 1620
RNSAPASMSP DGTRVIPRRS PLSYPAVNRY SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ 1680
PSPSTSSLSS THSASPNVTS SAPSSARASP LLSDKHKHSR ENSCLSPRDR PCSAIYPTPV 1740
EPSQRMLFNH IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP 1800
PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY NSPGLSSNSP VLSGSYSSGI 1860
SSLSRCSTSE TSGFENQANE QSVPVPVPVP VPVPVPSFSG SEEPVRKESK TPPPYSVYER 1920
TLRRPVPLPH SLSIPVTSEP PALPPKPLAA RSSHLENGTR RTEPGPRPRP LPRKVSQL 1978 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; ISS:UniProtKB. GO:0032420; C:stereocilium; IDA:HGNC. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0030675; F:Rac GTPase activator activity; IEA:Compara. GO:0060326; P:cell chemotaxis; ISS:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |