UniProt Accession

 S20A2_HUMAN; Q08357 

Genbank Protein ID

 L20852; AK291202; BC028600 

Genbank Nucleotide ID

 AAA18018.1; BAF83891.1; AAH28600.1 

Protein Name

 Sodium-dependent phosphate transporter 2 

Protein Synonyms/Alias

 Gibbon ape leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PiT-2; Pit2; hPit2; Solute carrier family 20 member 2 

Gene Name

 SLC20A2 

Gene Synonyms/Alias

 GLVR2; PIT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
262	VSDESLSKVQEAESP	ubiquitination	[1, 2]
272	EAESPVFKELPGAKA	ubiquitination	[1, 2, 3]
278	FKELPGAKANDDSTI	ubiquitination	[1, 2]
349	HVYHTVHKDSGLYKD	ubiquitination	[2]
360	LYKDLLHKIHIDRGP	ubiquitination	[1, 2]
370	IDRGPEEKPAQESNY	ubiquitination	[1, 2]
415	SAPEDSEKLVGDTVS	ubiquitination	[1, 2]
425	GDTVSYSKKRLRYDS	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. 

Sequence Annotation

 MOD_RES 268 268 Phosphoserine.
 CARBOHYD 81 81 N-linked (GlcNAc...).  

Keyword

 Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Ion transport; Membrane; Phosphate transport; Phosphoprotein; Receptor; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 652 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR001204; Phos_transporter. 

Pfam

 PF01384; PHO4 

SMART

  

PROSITE

  

PRINTS