| Tag | Content |
|---|
| CPLM ID | CPLM-019049 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-B-cell leukemia transcription factor-interacting protein 1 |
Protein Synonyms/Alias | Hematopoietic PBX-interacting protein |
Gene Name | PBXIP1 |
Gene Synonyms/Alias | HPIP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 634 | PWAGQLTKELPLSPA | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. |
Sequence Annotation | MOTIF 485 505 Nuclear localization signal (Potential).
MOTIF 695 720 Nuclear localization signal (Potential).
MOD_RES 43 43 Phosphoserine.
MOD_RES 146 146 Phosphoserine.
MOD_RES 147 147 Phosphoserine.
MOD_RES 148 148 Phosphoserine.
MOD_RES 152 152 Phosphothreonine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 731 AA |
Protein Sequence | MASCPDSDNS WVLAGSESLP VETLGPASRM DPESERALQA PHSPSKTDGK ELAGTMDGEG 60
TLFQTESPQS GSILTEETEV KGTLEGDVCG VEPPGPGDTV VQGDLQETTV VTGLGPDTQD 120
LEGQSPPQSL PSTPKAAWIR EEGRCSSSDD DTDVDMEGLR RRRGREAGPP QPMVPLAVEN 180
QAGGEGAGGE LGISLNMCLL GALVLLGLGV LLFSGGLSES ETGPMEEVER QVLPDPEVLE 240
AVGDRQDGLR EQLQAPVPPD SVPSLQNMGL LLDKLAKENQ DIRLLQAQLQ AQKEELQSLM 300
HQPKGLEEEN AQLRGALQQG EAFQRALESE LQQLRARLQG LEADCVRGPD GVCLSGGRGP 360
QGDKAIREQG PREQEPELSF LKQKEQLEAE AQALRQELER QRRLLGSVQQ DLERSLQDAS 420
RGDPAHAGLA ELGHRLAQKL QGLENWGQDP GVSANASKAW HQKSHFQNSR EWSGKEKWWD 480
GQRDRKAEHW KHKKEESGRE RKKNWGGQED REPAGRWKEG RPRVEESGSK KEGKRQGPKE 540
PPRKSGSFHS SGEKQKQPRW REGTKDSHDP LPSWAELLRP KYRAPQGCSG VDECARQEGL 600
TFFGTELAPV RQQELASLLR TYLARLPWAG QLTKELPLSP AFFGEDGIFR HDRLRFRDFV 660
DALEDSLEEV AVQQTGDDDE VDDFEDFIFS HFFGDKALKK RSGKKDKHSQ SPRAAGPREG 720
HSHSHHHHHR G 731 |
Gene Ontology | GO:0005829; C:cytosol; NAS:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003714; F:transcription corepressor activity; NAS:UniProtKB. GO:0030154; P:cell differentiation; NAS:UniProtKB. GO:0007275; P:multicellular organismal development; NAS:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB. |
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Pfam | |
SMART | |
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