CPLM-003895

Genbank Nucleotide ID

Protein Synonyms/Alias

Rattus norvegicus (Rat)

Position	Peptide	Type	References
8	MVKLIESKEAFQEAL	acetylation	[1]
39	CGPCKMIKPFFHSLC	acetylation	[1]
94	GEFSGANKEKLEATI	acetylation	[1]
96	FSGANKEKLEATITE	acetylation	[1]
96	FSGANKEKLEATITE	ubiquitination	[2]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).

DOMAIN 2 105 Thioredoxin.
ACT_SITE 32 32 Nucleophile (By similarity).
ACT_SITE 35 35 Nucleophile (By similarity).
MOD_RES 3 3 N6-acetyllysine (By similarity).
MOD_RES 39 39 N6-acetyllysine (By similarity).
MOD_RES 62 62 S-nitrosocysteine (By similarity).
MOD_RES 69 69 S-nitrosocysteine (By similarity).
MOD_RES 73 73 S-nitrosocysteine; alternate (By
DISULFID 32 35 Redox-active (By similarity).
DISULFID 73 73 Interchain; alternate (By similarity).

Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Electron transport; Nucleus; Redox-active center; Reference proteome; S-nitrosylation; Secreted; Transcription; Transcription regulation; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030424; C:axon; IDA:RGD.
GO:0005829; C:cytosol; IDA:RGD.
GO:0030425; C:dendrite; IDA:RGD.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IEA:Compara.
GO:0043025; C:neuronal cell body; IDA:RGD.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0015037; F:peptide disulfide oxidoreductase activity; IEA:Compara.
GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
GO:0004791; F:thioredoxin-disulfide reductase activity; TAS:RGD.
GO:0016999; P:antibiotic metabolic process; IEP:RGD.
GO:0045454; P:cell redox homeostasis; IEA:Compara.
GO:0035690; P:cellular response to drug; IEP:RGD.
GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO:0071455; P:cellular response to hyperoxia; IEP:RGD.
GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Compara.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
GO:0043388; P:positive regulation of DNA binding; ISS:UniProtKB.
GO:0033158; P:regulation of protein import into nucleus, translocation; ISS:UniProtKB.
GO:0014823; P:response to activity; IEP:RGD.
GO:0048678; P:response to axon injury; IEP:RGD.
GO:0071548; P:response to dexamethasone stimulus; IEP:RGD.
GO:0009314; P:response to radiation; ISS:UniProtKB.
GO:0010269; P:response to selenium ion; IEP:RGD.
GO:0097068; P:response to thyroxine stimulus; IEP:RGD.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

IPR005746; Thioredoxin.
IPR012336; Thioredoxin-like_fold.
IPR017937; Thioredoxin_CS.
IPR013766; Thioredoxin_domain.

PF00085; Thioredoxin

PS00194; THIOREDOXIN_1
PS51352; THIOREDOXIN_2

PR00421; THIOREDOXIN.