UniProt Accession

 MAGA6_HUMAN; P43360; A8IF93; Q6NW44 

Genbank Protein ID

 U10691; U10339; D32076; EU161101; BX640600; BC041599; BC067731 

Genbank Nucleotide ID

 AAA68875.1; AAA19006.1; BAA06842.1; ABW06860.1; CAE45706.1; AAH41599.1; AAH67731.1 

Protein Name

 Melanoma-associated antigen 6 

Protein Synonyms/Alias

 Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen 

Gene Name

 MAGEA6 

Gene Synonyms/Alias

 MAGE6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
244	SIFGDPKKLLTQYFV	ubiquitination	[1, 2, 3]
292	KVLHHMVKISGGPRI	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

 Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. 

Sequence Annotation

 DOMAIN 109 308 MAGE.  

Keyword

 Complete proteome; Polymorphism; Reference proteome; Tumor antigen; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR002190; MAGE.
 IPR021072; Melanoma_ass_antigen_N. 

Pfam

 PF01454; MAGE
 PF12440; MAGE_N 

SMART

  

PROSITE

 PS50838; MAGE 

PRINTS