UniProt Accession

 CAPZB_PIG; A0PFK7 

Genbank Protein ID

 AM410996 

Genbank Nucleotide ID

 CAL69437.1 

Protein Name

 F-actin-capping protein subunit beta 

Protein Synonyms/Alias

 CapZ beta 

Gene Name

 CAPZB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Sus scrofa (Pig) 

NCBI Taxa ID

 9823 

Lysine Modification

Position	Peptide	Type	References
78	YRSPWSNKYDPPLED	ubiquitination	[1]
95	MPSARLRKLEVEANN	ubiquitination	[1]
159	HVVEVQEKSSGRTAH	ubiquitination	[1]
223	LVEDMENKIRSTLNE	ubiquitination	[1]
235	LNEIYFGKTKDIVNG	ubiquitination	[1]
237	EIYFGKTKDIVNGLR	ubiquitination	[1]
254	DAIPDNHKFKQLQRE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). 

Sequence Annotation

 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 235 235 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin capping; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.