CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoid X receptor alpha 
Protein Synonyms/Alias
  
Gene Name
 Rxra 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MDTKHFLPLDFubiquitination[1]
386VLFNPDSKGLSNPAEubiquitination[1]
422EQPGRFAKLLLRLPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 DNA-binding; Metal-binding; Nucleus; Receptor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MDTKHFLPLD FSTQVNSSSL NSPTGRGSMA VPSLHPSLGP GIGSPLGSPG QLHSPISTLS 60
SPINGMGPPF SVISSPMGPH SMSVPTTPTL GFGTGSPQLN SPMNPVSSTE DIKPPLGLNG 120
VLKVPAHPSG NMASFTKHIC AICGDRSSGK HYGVYSCEGC KGFFKRTVRK DLTYTCRDNK 180
DCLIDKRQRN RCQYCRYQKC LAMGMKREAV QEERQRGKDR NENEVESTSS ANEDMPVEKI 240
LEAELAVEPK TETYVEANMG LNPSSPNDPV TNICQAADKQ LFTLVEWAKR IPHFSELPLD 300
DQVILLRAGW NELLIASFSH RSIAVKDGIL LATGLHVHRN SAHSAGVGAI FDRVLTELVS 360
KMRDMQMDKT ELGCLRAIVL FNPDSKGLSN PAEVEALREK VYASLEAYCK HKYPEQPGRF 420
AKLLLRLPAL RSIGLKCLEH LFFFKLIGDT PIDTFLMEML EAPHQAT 467 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004886; F:9-cis retinoic acid receptor activity; IDA:MGI.
 GO:0031490; F:chromatin DNA binding; IDA:MGI.
 GO:0044323; F:retinoic acid-responsive element binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IGI:MGI.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0070644; F:vitamin D response element binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060038; P:cardiac muscle cell proliferation; IMP:MGI.
 GO:0007566; P:embryo implantation; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0001893; P:maternal placenta development; IGI:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IMP:MGI.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; IMP:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.
 GO:0019048; P:virus-host interaction; IEA:Compara. 
Interpro
 IPR021780; Nuc_recep-AF1.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF11825; Nuc_recep-AF1
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.