CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023674
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM domain-containing protein 4B 
Protein Synonyms/Alias
 GRP1-binding protein GRSP1 
Gene Name
 FRMD4B 
Gene Synonyms/Alias
 KIAA1013 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
561EYRIRCGKKPSQKATacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity). 
Sequence Annotation
 DOMAIN 59 361 FERM.
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 674 674 Phosphotyrosine (By similarity).
 MOD_RES 697 697 Phosphoserine (By similarity).
 MOD_RES 915 915 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1034 AA 
Protein Sequence
MASVFMCGVE DLLFSGSRFV WNLTVSTLRR WYTERLRACH QVLRTWCGLQ DVYQMTEGRH 60
CQVHLLDDRR LELLVQPKLL ARELLDLVAS HFNLKEKEYF GITFIDDTGQ QNWLQLDHRV 120
LDHDLPKKPG PTILHFAVRF YIESISFLKD KTTVELFFLN AKACVHKGQI EVESETIFKL 180
AAFILQEAKG DYTSDENARK DLKTLPAFPT KTLQEHPSLA YCEDRVIEHY LKIKGLTRGQ 240
AVVQYMKIVE ALPTYGVHYY AVKDKQGLPW WLGISYKGIG QYDIQDKVKP RKLFQWKQLE 300
NLYFREKKFA VEVHDPRRIS VSRRTFGQSG LFVQTWYANS SLIKSIWVMA ISQHQFYLDR 360
KQSKAKIPSA RSLDEIAMDL TETGTQRASK LVTLETKSQF IMASNGSLIS SGSQDSEVSE 420
EQKREKILEL KKKEKLLQEK LLKKVEELKK ICLREAELTG KMPKEYPLNI GEKPPQVRRR 480
VGTAFKLDDN LLPSEEDPAL QELESNFLIQ QKLVEAAKKL ANEPDLCKTV KKKRKQDYTD 540
AMKKLQEIEN AINEYRIRCG KKPSQKATVL PEDIIPSESS SLSDTTTYDD PSDAFTFPGQ 600
RSSSVPHSPR ILPPKSLGIE RIHFRKSSIN EQFVDTRQSR EMLSTHSSPY KTLERRPQGG 660
RSMPTTPVLT RNAYSSSHLE PESSSQHCRQ RSGSLESQSH LLSEMDSDKP FFSLSKSQRS 720
SSTEILDDGS SYTSQSSTEY YCVTPVTGPY YTTQTLDTRT RGRRRSKKQN VSTSNSGSMP 780
NLAQKDSLRN GVYSKSQEPP SSSYYIAGYT PYAECDFYYS GGYVYENDTE GQYSVNPSYR 840
SSAHYGYERQ RDYSRSFHED EVDRVPHNPY ATLRLPRKAA AKSEHITKNI HKALVAEHLR 900
GWYQRASGQK DQGHSPQTSF DSDRGSQRCL GFAGLQVPCS PSSRASSYSS VSSTNASGNW 960
RTQLTIGLSD YETPAHSSYT SCYGNVYNPL PSPSRQYTEI SQLDGTDGNQ LEDNLESSEQ 1020
RLFWHEDSKP GTLV 1034 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0090162; P:establishment of epithelial cell polarity; IEA:Compara. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR021774; DUF3338.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom. 
Pfam
 PF11819; DUF3338
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.