UniProt Accession

 VTI1A_HUMAN; Q96AJ9; A2A307; B4E137; Q5W0D7 

Genbank Protein ID

 AK303646; AL139120; AC022018; AL158212; AL139120; AC022018; AL158212; AC022018; AL139120; CH471066; CH471066; BC017052 

Genbank Nucleotide ID

 BAG64649.1; CAH71781.2; CAH71781.2; CAH71781.2; CAM15142.1; CAM15142.1; CAM22437.1; CAM22437.1; CAM22437.1; EAW49524.1; EAW49525.1; AAH17052.1 

Protein Name

 Vesicle transport through interaction with t-SNAREs homolog 1A 

Protein Synonyms/Alias

 Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2 

Gene Name

 VTI1A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	RLPPDEKKQMVANVE	ubiquitination	[1]
43	QMVANVEKQLEEAKE	ubiquitination	[2, 3]
89	GKLETDFKRSRIAYS	ubiquitination	[1]
176	ETDANLGKSSRILTG	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. 

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; TAS:HGNC.
 GO:0005484; F:SNAP receptor activity; IDA:HGNC.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0042147; P:retrograde transport, endosome to Golgi; IDA:UniProtKB. 

Interpro

 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom.
 IPR007705; Vesicle_trsprt_v-SNARE_N. 

Pfam

 PF05008; V-SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

  

PRINTS