CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040386
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acyl carrier protein 
Protein Synonyms/Alias
  
Gene Name
 Ndufab1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
51PLTLDGIKDRVLYVLacetylation[1, 2]
59DRVLYVLKLYDKIDPacetylation[1, 2, 3, 4, 5]
63YVLKLYDKIDPEKLSacetylation[3, 5]
63YVLKLYDKIDPEKLSubiquitination[6]
68YDKIDPEKLSVNSHFacetylation[2, 5]
123VDYIADKKDVYE***acetylation[1]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Phosphopantetheine; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 127 AA 
Protein Sequence
RPLSTTLCPE GIRRRPGALQ SALALAQVPG TVTHLCRQYS DAPPLTLDGI KDRVLYVLKL 60
YDKIDPEKLS VNSHFMKDLG LDSLDQVEII MAMEDEFGFE IPDIDAEKLM CPQEIVDYIA 120
DKKDVYE 127 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0009249; P:protein lipoylation; IEA:Compara. 
Interpro
 IPR003231; Acyl_carrier.
 IPR009081; Acyl_carrier_prot-like.
 IPR006162; PPantetheine_attach_site. 
Pfam
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00012; PHOSPHOPANTETHEINE 
PRINTS