CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inositol 1,4,5-trisphosphate receptor type 3 
Protein Synonyms/Alias
  
Gene Name
 Itpr3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1111VENYKVIKSELDRLRacetylation[1]
1728ATQCRLDKEGATKLVacetylation[1]
1785KKSERFFKVLHDRMKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2668 AA 
Protein Sequence
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 60
PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 120
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 180
DKVILNPVNA GQPLHASNYE LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 240
VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 300
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI KYRLVAVPHG 360
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNAPIDVEEE RPIRLMLGTC 420
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 480
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE 540
LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 600
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE LICKCVLDPK 660
NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA 720
HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISKQLGVELL FLCMADEMLP FDLRASFCHL 780
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY 840
LNNVVGEAVP FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 900
VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ LDRSKFEDNE 960
HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSST 1020
ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLL HLTMHDYPPL VSGALQLLFK 1080
HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE 1140
AGASKDKKER PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 1200
DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL QLFLTPGLLE 1260
AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM 1320
IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 1380
VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 1440
FENFTLDMAL VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 1500
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA LLSSGGSCSA 1560
AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDM 1620
LHWPELLFLE GSEAYQRCES GGFLSKAPRA RDGSRRPPKS VCFCHRLIRH MLQKKSKYGD 1680
RGNQLRKMLL QNSSDRKPGP RGELTDPTGS GVDQDWSAIA ATQCRLDKEG ATKLVCDLIT 1740
STKNEKIFQE SIGLAIRLLD GGNTEIQKSF YNLMTSDKKS ERFFKVLHDR MKRAQQETKS 1800
TVAVNMSDLG SQPREDREPA DPTTKGRVSS FSMPSSSRYS LGPGLHRGHD VSERAQNNEM 1860
GTSVLIMRPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG 1920
LLGLYINEDN VGLVIQTLET LTEYCQGPCH ENQTCIVTHE SNGIDIITAL ILNDISPLCK 1980
YRMDLVLQLK DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEERENSE 2040
VSPREVGHNI YILALQLSRH NKQLQHLLKP VKRIQEEEAE GISSMLSLNN KQLSQMLKSS 2100
APAQEEEEDP LAYYENHTSQ IEIVRQDRSM EQIVFPVPAI CQFLTEETKH RLFTTTEQDE 2160
QGSKVSDFFD QSSFLHNEME WQRRLRSMPL IYWFSRRMTL WGSISFNLAV FINIIIAFFY 2220
PYVEGASTGV LGSPLISLLF WILICFSIAA LFTKHYSVRP LIVALVLRSI YYLGIGPTLN 2280
ILGALNLTNK IVFVVSFVGN RGTFIRGYKA MVMDMEFLYH VGYILTSVLG LFAHELFYSI 2340
LLFDLIYREE TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP 2400
GNHSRASTLG MPHGAATFMG TCSGDKMDCV SEVSVPEILE EDEELDSTER ACDTLLMCIV 2460
TVMNHGLRNG GGVGDILRKP SKDESLFPAR VVYDLLFFFI VIIIVLNLIF GVIIDTFADL 2520
RSEKQKKEEI LKTTCFICGL ERDKFDNKTV SFEEHIKLEH NMWNYLYFIV LVRVKNKTDY 2580
TGPESYVAQM IKNKNLDWFP RMRAMSLVSG EGEGEQNEIR ILQEKLGSTM KLVSHLTAQL 2640
NELKEQMTEQ RKRRQRLGFV DVQNCMSR 2668 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
 GO:0048016; P:inositol phosphate-mediated signaling; IEA:GOC. 
Interpro
 IPR000699; Ca-rel_channel.
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF01365; RYDR_ITPR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.