CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA 
Protein Synonyms/Alias
 PPIase; Rotamase 
Gene Name
 fkpA 
Gene Synonyms/Alias
 yzzS; b3347; JW3309 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
42ADSKAAFKNDDQKSAacetylation[1]
47AFKNDDQKSAYALGAacetylation[1]
69NSLKEQEKLGIKLDKacetylation[1]
76KLGIKLDKDQLIAGVacetylation[1]
90VQDAFADKSKLSDQEacetylation[1]
92DAFADKSKLSDQEIEacetylation[1]
119SAQAKMEKDAADNEAacetylation[1]
179KGTLIDGKEFDNSYTacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 
Sequence Annotation
 DOMAIN 164 249 PPIase FKBP-type.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Periplasm; Reference proteome; Rotamase; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 270 AA 
Protein Sequence
MKSLFKVTLL ATTMAVALHA PITFAAEAAK PATAADSKAA FKNDDQKSAY ALGASLGRYM 60
ENSLKEQEKL GIKLDKDQLI AGVQDAFADK SKLSDQEIEQ TLQAFEARVK SSAQAKMEKD 120
AADNEAKGKE YREKFAKEKG VKTSSTGLVY QVVEAGKGEA PKDSDTVVVN YKGTLIDGKE 180
FDNSYTRGEP LSFRLDGVIP GWTEGLKNIK KGGKIKLVIP PELAYGKAGV PGIPPNSTLV 240
FDVELLDVKP APKADAKPEA DAKAADSAKK 270 
Gene Ontology
 GO:0016020; C:membrane; ISS:RefGenome.
 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0005528; F:FK506 binding; ISS:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:RefGenome.
 GO:0042026; P:protein refolding; IDA:EcoliWiki. 
Interpro
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR000774; PPIase_FKBP_N. 
Pfam
 PF00254; FKBP_C
 PF01346; FKBP_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS