CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003292
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha 
Protein Synonyms/Alias
 ACCase subunit alpha; Acetyl-CoA carboxylase carboxyltransferase subunit alpha 
Gene Name
 accA 
Gene Synonyms/Alias
 b0185; JW0180 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
31AVSRQDEKLDINIDEacetylation[1]
46EVHRLREKSVELTRKacetylation[1]
53KSVELTRKIFADLGAacetylation[1]
99DRAYADDKAIVGGIAacetylation[1]
243ILWKSADKAPLAAEAacetylation[1]
259GIIAPRLKELKLIDSacetylation[1]
262APRLKELKLIDSIIPacetylation[1]
306VLSTEDLKNRRYQRLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. 
Sequence Annotation
  
Keyword
 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Ligase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL TRKIFADLGA 60
WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA IVGGIARLDG RPVMIIGHQK 120
GRETKEKIRR NFGMPAPEGY RKALRLMQMA ERFKMPIITF IDTPGAYPGV GAEERGQSEA 180
IARNLREMSR LGVPVVCTVI GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS 240
ADKAPLAAEA MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL 300
STEDLKNRRY QRLMSYGYA 319 
Gene Ontology
 GO:0009329; C:acetate CoA-transferase complex; IDA:EcoCyc.
 GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042759; P:long-chain fatty acid biosynthetic process; NAS:EcoliWiki.
 GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001095; Acetyl_CoA_COase_a_su.
 IPR011763; COA_CT_C. 
Pfam
 PF03255; ACCA 
SMART
  
PROSITE
 PS50989; COA_CT_CTER 
PRINTS
 PR01069; ACCCTRFRASEA.