CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Metastasis-associated protein MTA1 
Protein Synonyms/Alias
  
Gene Name
 MTA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32RRIEELNKTANGNVEubiquitination[1, 2, 3]
100VDLPEKLKHQLRHREubiquitination[2]
125PATHIRGKCSVTLLNubiquitination[2]
208AHNPLTDKQIDQFLVubiquitination[1, 4]
260HAMDTLHKNIYDISKubiquitination[4]
361VYIPNYNKPNPNQISubiquitination[4]
527SQSPLVLKQAVRKPLubiquitination[2, 3, 4]
582GSPTILGKRSYEQHNubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 703 AA 
Protein Sequence
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSTLIALAD 60
KHATLSVCYK AGPGADNGEE GEIEEEMENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT 120
HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL 180
LKEGEEDGRD QSRLETQVWE AHNPLTDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM 240
SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 300
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN 360
KPNPNQISVN NVKAGVVNGT GAPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC 420
WTYWKKYGGL KMPTRLDGER PGPNRSNMSP HGLPARSSGS PKFAMKTRQA FYLHTTKLTR 480
IARRLCREIL RPWHAARHPY LPINSAAIKA ECTARLPEAS QSPLVLKQAV RKPLEAVLRY 540
LETHPRPPKP DPVKSVSSVL SSLTPAKVAP VINNGSPTIL GKRSYEQHNG VDGLANHGQA 600
RHMGPSRNLL LNGKSYPTKV RLIRGGSLPP VKRRRMNWID APDDVFYMAT EETRKIRKLL 660
SSSETKRAAR RPYKPIALRQ SQALPPRPPP PAPVNDEPIV IED 703 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001025; BAH_dom.
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR000679; Znf_GATA. 
Pfam
 PF01426; BAH
 PF01448; ELM2
 PF00320; GATA 
SMART
 SM00439; BAH
 SM00717; SANT
 SM00401; ZnF_GATA 
PROSITE
 PS51038; BAH
 PS51156; ELM2
 PS51293; SANT 
PRINTS