CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002875
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tryptophan synthase beta chain 
Protein Synonyms/Alias
  
Gene Name
 trpB 
Gene Synonyms/Alias
 STM1726 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
382NLSGRGDKDIFTVHDacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. 
Sequence Annotation
 MOD_RES 87 87 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome; Tryptophan biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 397 AA 
Protein Sequence
MTTLLNPYFG EFGGMYVPQI LMPALNQLEE AFVSAQKDPE FQAQFADLLK NYAGRPTALT 60
KCQNITAGTR TTLYLKREDL LHGGAHKTNQ VLGQALLAKR MGKSEIIAET GAGQHGVASA 120
LASALLGLKC RIYMGAKDVE RQSPNVFRMR LMGAEVIPVH SGSATLKDAC NEALRDWSGS 180
YETAHYMLGT AAGPHPYPTI VREFQRMIGE ETKAQILDKE GRLPDAVIAC VGGGSNAIGM 240
FADFINDTSV GLIGVEPGGH GIETGEHGAP LKHGRVGIYF GMKAPMMQTA DGQIEESYSI 300
SAGLDFPSVG PQHAYLNSIG RADYVSITDD EALEAFKTLC RHEGIIPALE SSHALAHALK 360
MMREQPEKEQ LLVVNLSGRG DKDIFTVHDI LKARGEI 397 
Gene Ontology
 GO:0004834; F:tryptophan synthase activity; IEA:HAMAP. 
Interpro
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
 IPR006653; Trp_synth_b_CS.
 IPR006654; Trp_synth_beta.
 IPR023026; Trp_synth_beta/beta-like. 
Pfam
 PF00291; PALP 
SMART
  
PROSITE
 PS00168; TRP_SYNTHASE_BETA 
PRINTS