CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005532
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tristetraprolin 
Protein Synonyms/Alias
 TTP; G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; Protein TIS11A; TIS11; Zinc finger protein 36 homolog; Zfp-36 
Gene Name
 ZFP36 
Gene Synonyms/Alias
 G0S24; RNF162A; TIS11A; TTP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123GRCRYGAKCQFAHGLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). 
Sequence Annotation
 REPEAT 71 75 P-P-P-P-G.
 REPEAT 198 202 P-P-P-P-G.
 REPEAT 219 223 P-P-P-P-G.
 ZN_FING 103 131 C3H1-type 1.
 ZN_FING 141 169 C3H1-type 2.
 MOD_RES 60 60 Phosphoserine; by MAPKAPK2.
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 88 88 Phosphoserine.
 MOD_RES 90 90 Phosphoserine (By similarity).
 MOD_RES 92 92 Phosphothreonine.
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 186 186 Phosphoserine; by MAPKAPK2.
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 218 218 Phosphoserine.
 MOD_RES 228 228 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 296 296 Phosphoserine.
 MOD_RES 323 323 Phosphoserine (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS 60
LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY 120
GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV 180
LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL 240
ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE 300
AGVFAPPQPV AAPRRLPIFN RISVSE 326 
Gene Ontology
 GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.
 GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; IDA:MGI.
 GO:0003727; F:single-stranded RNA binding; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:UniProtKB.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0006402; P:mRNA catabolic process; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0035278; P:negative regulation of translation involved in gene silencing by miRNA; ISS:UniProtKB.
 GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.
 GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IDA:UniProtKB.
 GO:0032680; P:regulation of tumor necrosis factor production; IDA:UniProtKB.
 GO:0006950; P:response to stress; IDA:UniProtKB. 
Interpro
 IPR000571; Znf_CCCH. 
Pfam
 PF00642; zf-CCCH 
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1 
PRINTS