UniProt Accession

 CXB2_HUMAN; P29033; Q508A5; Q508A6; Q5YLL0; Q5YLL1; Q5YLL4; Q6IPV5; Q86U88; Q96AK0; Q9H536; Q9NNY4 

Genbank Protein ID

 M86849; AF281280; AF479776; AY255853; AY275646; AY275647; AY275648; AY275649; AY275650; AY275651; AY275652; AY275653; AY275654; AY280971; AY953438; AY953441; BT006732; AL138688; BC017048; BC071703 

Genbank Nucleotide ID

 AAD21314.1; AAF91440.1; AAL87696.1; AAP34178.1; AAQ94940.1; AAQ94941.1; AAQ94942.1; AAQ94943.1; AAQ94944.1; AAQ94945.1; AAQ94946.1; AAQ94947.1; AAQ94948.1; AAQ17213.1; AAY25169.1; AAY25170.1; AAP35378.1; CAC16959.1; AAH17048.1; AAH71703.1 

Protein Name

 Gap junction beta-2 protein 

Protein Synonyms/Alias

 Connexin-26; Cx26 

Gene Name

 GJB2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	TILGGVNKHSTSIGK	acetylation	[1]
102	VAYRRHEKKRKFIKG	acetylation	[1]
103	AYRRHEKKRKFIKGE	acetylation	[1]
105	RRHEKKRKFIKGEIK	acetylation	[1]
108	EKKRKFIKGEIKSEF	acetylation	[1]
108	EKKRKFIKGEIKSEF	ubiquitination	[2]
112	KFIKGEIKSEFKDIE	acetylation	[1]
112	KFIKGEIKSEFKDIE	ubiquitination	[2, 3]
116	GEIKSEFKDIEEIKT	acetylation	[1]
116	GEIKSEFKDIEEIKT	ubiquitination	[2, 3]
122	FKDIEEIKTQKVRIE	ubiquitination	[2, 3]

Reference

 [1] Post-translational modifications of connexin26 revealed by mass spectrometry.
 Locke D, Bian S, Li H, Harris AL.
 Biochem J. 2009 Dec 10;424(3):385-98. [PMID: 19775242]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 

Sequence Annotation

 DISULFID 53 180
 DISULFID 60 174
 DISULFID 64 169  

Keyword

 3D-structure; Cell junction; Cell membrane; Complete proteome; Deafness; Disease mutation; Disulfide bond; Ectodermal dysplasia; Gap junction; Hearing; Ichthyosis; Membrane; Non-syndromic deafness; Palmoplantar keratoderma; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005922; C:connexon complex; TAS:ProtInc.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0005243; F:gap junction channel activity; IEA:Compara.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016264; P:gap junction assembly; TAS:Reactome.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0007605; P:sensory perception of sound; TAS:ProtInc.
 GO:0006810; P:transport; TAS:ProtInc. 

Interpro

 IPR000500; Connexin.
 IPR002268; Connexin26.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.
 PR01139; CONNEXINB2.