CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014486
UniProt Accession
Genbank Protein ID
 D16102 
Genbank Nucleotide ID
Protein Name
 Glycerol kinase 
Protein Synonyms/Alias
 GK; Glycerokinase; ATP-stimulated glucocorticoid-receptor translocation promoter; ASTP; ATP:glycerol 3-phosphotransferase 
Gene Name
 Gk 
Gene Synonyms/Alias
 Gyk 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
125RTQSTVEKLSKRIPGubiquitination[1]
340RDNLGIIKSSEEIEKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. 
Sequence Annotation
 NP_BIND 427 431 ATP (By similarity).
 BINDING 20 20 Substrate (By similarity).
 BINDING 24 24 ATP (By similarity).
 BINDING 94 94 Substrate (By similarity).
 BINDING 148 148 Substrate (By similarity).
 BINDING 259 259 Substrate (By similarity).
 BINDING 281 281 ATP (By similarity).
 BINDING 326 326 ATP; via carbonyl oxygen (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Glycerol metabolism; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MAAAKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 60
LQSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKLTGEPLYN AVVWLDLRTQ 120
STVEKLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VKKVQEAVEE NRALFGTIDS 180
WLIWSLTGGI NGGVHCTDVT NASRTMLFNI HSLEWDKELC EFFGIPMEIL PNVRSSSEIY 240
GLMKAGALEG VPISGCLGDQ SAALVGQMCF QDGQAKNTYG TGCFLLCNTG HKCVFSEHGL 300
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK SSEEIEKLAK EVGTSYGCYF 360
VPAFSALYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV CFQTREILDA MNRDCGIPLS 420
HLQVDGGMTS NKILMQLQAD ILYIPVVKPS MPETTALGAA MAAGAAEGVG VWSLEPEDLS 480
AVTMERFEPQ INAEESEIRY STWKKAVMKS IGWVTTQSPE SGIP 524 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004370; F:glycerol kinase activity; IEA:EC.
 GO:0042393; F:histone binding; IDA:RGD.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
 GO:0009409; P:response to cold; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IDA:RGD. 
Interpro
 IPR018485; Carb_kinase_FGGY_C.
 IPR018483; Carb_kinase_FGGY_CS.
 IPR018484; Carb_kinase_FGGY_N.
 IPR005999; Glycerol_kin. 
Pfam
 PF02782; FGGY_C
 PF00370; FGGY_N 
SMART
  
PROSITE
 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 
PRINTS