| Tag | Content |
|---|
| CPLM ID | CPLM-018751 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/hydrogen exchanger 6 |
Protein Synonyms/Alias | Na(+)/H(+) exchanger 6; NHE-6; Solute carrier family 9 member 6 |
Gene Name | SLC9A6 |
Gene Synonyms/Alias | KIAA0267; NHE6 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 560 | ENERRTTKAESAWLF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. |
Sequence Annotation | CARBOHYD 128 128 N-linked (GlcNAc...).
CROSSLNK 443 443 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Antiport; Complete proteome; Endosome; Epilepsy; Glycoprotein; Ion transport; Isopeptide bond; Membrane; Mental retardation; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MARRGWRRAP LRRGVGSSPR ARRLMRPLWL LLAVGVFDWA GASDGGGGEA RAMDEEIVSE 60
KQAEESHRQD SANLLIFILL LTLTILTIWL FKHRRARFLH ETGLAMIYGL LVGLVLRYGI 120
HVPSDVNNVT LSCEVQSSPT TLLVNVSGKF YEYMLKGEIS SHELNNVQDN EMLRKVTFDP 180
EVFFNILLPP IIFYAGYSLK RRHFFRNLGS ILAYAFLGTA ISCFVIGSIM YGCVTLMKVT 240
GQLAGDFYFT DCLLFGAIVS ATDPVTVLAI FHELQVDVEL YALLFGESVL NDAVAIVLSS 300
SIVAYQPAGD NSHTFDVTAM FKSIGIFLGI FSGSFAMGAA TGVVTALVTK FTKLREFQLL 360
ETGLFFLMSW STFLLAEAWG FTGVVAVLFC GITQAHYTYN NLSTESQHRT KQLFELLNFL 420
AENFIFSYMG LTLFTFQNHV FNPTFVVGAF VAIFLGRAAN IYPLSLLLNL GRRSKIGSNF 480
QHMMMFAGLR GAMAFALAIR DTATYARQMM FSTTLLIVFF TVWVFGGGTT AMLSCLHIRV 540
GVDSDQEHLG VPENERRTTK AESAWLFRMW YNFDHNYLKP LLTHSGPPLT TTLPACCGPI 600
ARCLTSPQAY ENQEQLKDDD SDLILNDGDI SLTYGDSTVN TEPATSSAPR RFMGNSSEDA 660
LDRELAFGDH ELVIRGTRLV LPMDDSEPPL NLLDNTRHGP A 701 |
Gene Ontology | GO:0031901; C:early endosome membrane; IDA:UniProtKB. GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0055038; C:recycling endosome membrane; IDA:UniProtKB. GO:0015385; F:sodium:hydrogen antiporter activity; TAS:ProtInc. GO:0006885; P:regulation of pH; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |