UniProt Accession

 ATF5_HUMAN; Q9Y2D1; B3KND3; Q9BSA1; Q9UNQ3 

Genbank Protein ID

 AF305687; AB073613; AB021663; AK024402; AC011452; CH471177; BC005174; AF101388 

Genbank Nucleotide ID

 AAG22558.1; BAD38650.1; BAA78477.2; BAG51295.1; EAW52581.1; AAH05174.1; AAD28370.1 

Protein Name

 Cyclic AMP-dependent transcription factor ATF-5 

Protein Synonyms/Alias

 cAMP-dependent transcription factor ATF-5; Activating transcription factor 5; Transcription factor ATFx 

Gene Name

 ATF5 

Gene Synonyms/Alias

 ATFX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	GWLVDYGKLPPAPAP	acetylation	[1]
229	ALRYRQRKRAEGEAL	ubiquitination	[2]

Reference

 [1] p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.
 Liu DX, Qian D, Wang B, Yang JM, Lu Z.
 Mol Cell Biol. 2011 Sep;31(18):3906-16. [PMID: 21791614]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. 

Sequence Annotation

 DOMAIN 208 271 bZIP.
 REGION 119 217 Interaction with PTP4A1 (By similarity).
 REGION 210 230 Basic motif (By similarity).
 REGION 236 250 Leucine-zipper (By similarity).  

Keyword

 Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS