UniProt Accession

 NUP53_MOUSE; Q8R4R6; A2ATJ3; Q9D7J2 

Genbank Protein ID

 AF411517; AK009187; AK089997; AK136109; AK145775; AL928869; BC048814 

Genbank Nucleotide ID

 AAL86380.1; BAB26128.1; BAC41034.1; BAE22825.1; BAE26644.1; CAM23081.1; AAH48814.1 

Protein Name

 Nucleoporin NUP53 

Protein Synonyms/Alias

 35 kDa nucleoporin; Mitotic phosphoprotein 44; MP-44; Nuclear pore complex protein Nup53; Nucleoporin Nup35 

Gene Name

 Nup35 

Gene Synonyms/Alias

 Mp44; Nup53 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
293	RPLATAYKASTSDYQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity). 

Sequence Annotation

 DOMAIN 169 249 RRM Nup35-type.
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 73 73 Phosphoserine (By similarity).
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphoserine (By similarity).
 MOD_RES 106 106 Phosphothreonine (By similarity).
 MOD_RES 121 121 Phosphoserine (By similarity).
 MOD_RES 128 128 Phosphothreonine (By similarity).
 MOD_RES 137 137 Phosphoserine (By similarity).
 MOD_RES 264 264 Phosphothreonine (By similarity).
 MOD_RES 272 272 Phosphothreonine (By similarity).
 MOD_RES 278 278 Phosphoserine (By similarity).
 MOD_RES 279 279 Phosphothreonine (By similarity).
 MOD_RES 307 307 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR017389; Nucleoporin_NUP53.
 IPR007846; RRM_NUP35_dom. 

Pfam

 PF05172; Nup35_RRM 

SMART

  

PROSITE

 PS51472; RRM_NUP35 

PRINTS