CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein TolA 
Protein Synonyms/Alias
  
Gene Name
 tolA 
Gene Synonyms/Alias
 cim; excC; lky; b0739; JW0729 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
10KATEQNDKLKRAIIIacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA. 
Sequence Annotation
 REPEAT 224 229 1.
 REPEAT 230 234 2.
 REPEAT 235 240 3.
 REPEAT 241 245 4.
 REPEAT 246 250 5.
 REPEAT 251 255 6.
 REPEAT 256 260 7.
 REPEAT 261 266 8.
 REPEAT 267 271 9.
 REPEAT 272 277 10.
 REPEAT 278 282 11.
 REPEAT 283 287 12.
 REPEAT 288 292 13.
 REGION 48 310 Domain II (alpha-helical).
 REGION 224 292 13 X tandem repeats of [EDA]-K(1,2)-
 REGION 311 421 Domain III (functional).
 DISULFID 363 388  
Keyword
 3D-structure; Bacteriocin transport; Cell inner membrane; Cell membrane; Complete proteome; Disulfide bond; Membrane; Protein transport; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 421 AA 
Protein Sequence
MSKATEQNDK LKRAIIISAV LHVILFAALI WSSFDENIEA SAGGGGGSSI DAVMVDSGAV 60
VEQYKRMQSQ ESSAKRSDEQ RKMKEQQAAE ELREKQAAEQ ERLKQLEKER LAAQEQKKQA 120
EEAAKQAELK QKQAEEAAAK AAADAKAKAE ADAKAAEEAA KKAAADAKKK AEAEAAKAAA 180
EAQKKAEAAA AALKKKAEAA EAAAAEARKK AATEAAEKAK AEAEKKAAAE KAAADKKAAA 240
EKAAADKKAA EKAAAEKAAA DKKAAAEKAA ADKKAAAAKA AAEKAAAAKA AAEADDIFGE 300
LSSGKNAPKT GGGAKGNNAS PAGSGNTKNN GASGADINNY AGQIKSAIES KFYDASSYAG 360
KTCTLRIKLA PDGMLLDIKP EGGDPALCQA ALAAAKLAKI PKPPSQAVYE VFKNAPLDFK 420
P 421 
Gene Ontology
 GO:0016021; C:integral to membrane; IDA:EcoliWiki.
 GO:0005886; C:plasma membrane; IDA:EcoliWiki.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0043213; P:bacteriocin transport; IMP:EcoliWiki.
 GO:0017038; P:protein import; IMP:EcoliWiki. 
Interpro
 IPR014161; Tol-Pal_TolA. 
Pfam
 PF06519; TolA 
SMART
  
PROSITE
  
PRINTS