CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037107
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
  
Gene Name
 ABCA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1145EDLELSNKRHSLVQTubiquitination[1]
1158QTLSGGMKRKLSVAIubiquitination[1]
1252GYRLTLVKRPAEPGGubiquitination[2]
1366ENSEADVKESRKDVLubiquitination[2, 3]
1734ITFGNVLKSIPASFGubiquitination[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2024 AA 
Protein Sequence
MGRKTSRVQQ GPPRSPACSA HGERSWGLEF PPFRWLLGIA GRTHLAALPP FQWVLAFEIF 60
IPLVLFFILL GLRQKKPTIS VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS 120
TVTQLLERLD RVVEEGNLFD PARPSLGSEL EALRQHLEAL SAGPGTSGSH LDRSTVSSFS 180
LDSVARNPQE LWRFLTQNLS LPNSTAQALL AARVDPPEVY HLLFGPSSAL DSQSGLHKGQ 240
EPWSRLGGNP LFRMEELLLA PALLEQLTCT PGSGELGRIL TVPESQKGAL QGYRDAVCSG 300
QAAARARRFS GLSAELRNQL DVAKVSQQLG LDAPNGSDSS PQAPPPRRLQ ALLGDLLDAQ 360
KVLQDVDVLS ALALLLPQGA CTGRTPGPPA SGAGGAANGT GAGAVMGPNA TAEEGAPSAA 420
ALATPDTLQG QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV 480
HLMTSNPKIL YAPAGSEVDR VILKANETFA FVGNVTHYAQ VWLNISAEIR SFLEQGRLQQ 540
HLRWLQQYVA ELRLHPEALN LSLDELPPAL RQDNFSLPSG MALLQQLDTI DNAACGWIQF 600
MSKVSVDIFK GFHDEESIVN YTLNQAYQDN VTVFASVIFQ TRKDGSLPPH VHYKIRQNSS 660
FTEKTNEIRR AYWRPGPNTG GRFYFLYGFV WIQDMMERAI IDTFVGHDVV EPGSYVQMFP 720
YPCYTRDDFL FVIEHMMPLC MVISWVYSVA MTIQHIVAEK EHRLKEVMKT MGLNNAVHWV 780
AWFITGFVQL SISVTALTAI LKYGQVLMHS HVVIIWLFLA VYAVATIMFC FLVSVLYSKA 840
KLASACGGII YFLSYVPYMY VAIREEVAHD KITAFEKCIA SLMSTTAFGL GSKYFALYEV 900
AGVGIQWHTF SQSPVEGDDF NLLLAVTMLM VDAVVYGILT WYIEAVHPGM YGLPRPWYFP 960
LQKSYWLGSG RTEAWEWSWP WARTPRLSVM EEDQACAMES RRFEETRGME EEPTHLPLVV 1020
CVDKLTKVYK DDKKLALNKL SLNLYENQVV SFLGHNGAGK TTTMSILTGL FPPTSGSATI 1080
YGHDIRTEMD EIRKNLGMCP QHNVLFDRLT VEEHLWFYSR LKSMAQEEIR REMDKMIEDL 1140
ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG SRAIILDEPT AGVDPYARRA IWDLILKYKP 1200
GRTILLSTHH MDEADLLGDR IAIISHGKLK CCGSPLFLKG TYGDGYRLTL VKRPAEPGGP 1260
QEPGLASSPP GRAPLSSCSE LQVSQFIRKH VASCLLVSDT STELSYILPS EAAKKGAFER 1320
LFQHLERSLD ALHLSSFGLM DTTLEEVFLK VSEEDQSLEN SEADVKESRK DVLPGAEGPA 1380
SGEGHAGNLA RCSELTQSQA SLQSASSVGS ARGDEGAGYT DVYGDYRPLF DNPQDPDNVS 1440
LQEVEAEALS RVGQGSRKLD GGWLKVRQFH GLLVKRFHCA RRNSKALFSQ ILLPAFFVCV 1500
AMTVALSVPE IGDLPPLVLS PSQYHNYTQP RGNFIPYANE ERREYRLRLS PDASPQQLVS 1560
TFRLPSGVGA TCVLKSPANG SLGPTLNLSS GESRLLAARF FDSMCLESFT QGLPLSNFVP 1620
PPPSPAPSDS PASPDEDLQA WNVSLPPTAG PEMWTSAPSL PRLVREPVRC TCSAQGTGFS 1680
CPSSVGGHPP QMRVVTGDIL TDITGHNVSE YLLFTSDRFR LHRYGAITFG NVLKSIPASF 1740
GTRAPPMVRK IAVRRAAQVF YNNKGYHSMP TYLNSLNNAI LRANLPKSKG NPAAYGITVT 1800
NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV AMSFVPASFV VFLVAEKSTK AKHLQFVSGC 1860
NPIIYWLANY VWDMLNYLVP ATCCVIILFV FDLPAYTSPT NFPAVLSLFL LYGWSITPIM 1920
YPASFWFEVP SSAYVFLIVI NLFIGITATV ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN 1980
YNLGHGLMEM AYNEYINEYY AKIGEGARGA GKAVGAPQGP EHRP 2024 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS