CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042713
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myc proto-oncogene protein 
Protein Synonyms/Alias
  
Gene Name
 MYC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337RKDYPAAKRVKLDSVacetylation[1]
337RKDYPAAKRVKLDSVubiquitination[2]
369SDTEENVKRRTHNVLubiquitination[2]
403PELENNEKAPKVVILubiquitination[1, 2, 3, 4, 5]
412PKVVILKKATAYILSubiquitination[4]
426SVQAEEQKLISEEDLubiquitination[2, 3, 5]
444RREQLKHKLEQLRNSubiquitination[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
LDFFRVVENQ PPATMPLNVS FTNRNYDLDY DSVQPYFYCD EEENFYQQQQ QSELQPPAPS 60
EDIWKKFELL PTPPLSPSRR SGLCSPSYVA VTPFSLRGDN DGGGGSFSTA DQLEMVTELL 120
GGDMVNQSFI CDPDDETFIK NIIIQDCMWS GFSAAAKLVS EKLASYQAAR KDSGSPNPAR 180
GHSVCSTSSL YLQDLSAAAS ECIDPSVVFP YPLNDSSSPK SCASQDSSAF SPSSDSLLSS 240
TESSPQGSPE PLVLHEETPP TTSSDSEEEQ EDEEEIDVVS VEKRQAPGKR SESGSPSAGG 300
HSKPPHSPLV LKRCHVSTHQ HNYAAPPSTR KDYPAAKRVK LDSVRVLRQI SNNRKCTSPR 360
SSDTEENVKR RTHNVLERQR RNELKRSFFA LRDQIPELEN NEKAPKVVIL KKATAYILSV 420
QAEEQKLISE EDLLRKRREQ LKHKLEQLRN SCA 453 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR011598; bHLH_dom.
 IPR003327; Myc-LZ.
 IPR002418; Tscrpt_reg_Myc.
 IPR012682; Tscrpt_reg_Myc_N. 
Pfam
 PF00010; HLH
 PF02344; Myc-LZ
 PF01056; Myc_N 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS
 PR00044; LEUZIPPRMYC.