UniProt Accession

 PGK1_RAT; P16617; Q5M945; Q6P508 

Genbank Protein ID

 M31788; BC063161; BC087651 

Genbank Nucleotide ID

 AAA41838.1; AAH63161.1; AAH87651.1 

Protein Name

 Phosphoglycerate kinase 1 

Protein Synonyms/Alias

  

Gene Name

 Pgk1 

Gene Synonyms/Alias

 Pgk-1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
30	VDFNVPMKNNQITNN	acetylation	[1]
30	VDFNVPMKNNQITNN	ubiquitination	[2]
48	KAAVPSIKFCLDNGA	acetylation	[1]
75	DGVPMPDKYSLEPVA	acetylation	[1]
141	DASGNKVKAEPAKID	ubiquitination	[2]
146	KVKAEPAKIDAFRAS	acetylation	[1]
146	KVKAEPAKIDAFRAS	ubiquitination	[2]
216	LAILGGAKVADKIQL	acetylation	[1]
220	GGAKVADKIQLINNM	acetylation	[1]
264	LYDEEGAKIVKDLMA	acetylation	[1]
264	LYDEEGAKIVKDLMA	ubiquitination	[2]
267	EEGAKIVKDLMAKAE	acetylation	[1]
267	EEGAKIVKDLMAKAE	ubiquitination	[2]
272	IVKDLMAKAEKNGVK	acetylation	[1]
353	EAFARGTKSLMDEVV	acetylation	[1]
361	SLMDEVVKATSRGCI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

  

Sequence Annotation

 NP_BIND 373 376 ATP (By similarity).
 REGION 24 26 Substrate binding (By similarity).
 REGION 63 66 Substrate binding (By similarity).
 BINDING 39 39 Substrate (By similarity).
 BINDING 123 123 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 220 220 ATP (By similarity).
 BINDING 313 313 ATP; via carbonyl oxygen (By similarity).
 BINDING 344 344 ATP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 11 11 N6-acetyllysine (By similarity).
 MOD_RES 48 48 N6-acetyllysine (By similarity).
 MOD_RES 75 75 N6-acetyllysine (By similarity).
 MOD_RES 76 76 Phosphotyrosine (By similarity).
 MOD_RES 86 86 N6-acetyllysine (By similarity).
 MOD_RES 97 97 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine; alternate (By
 MOD_RES 131 131 N6-malonyllysine; alternate (By
 MOD_RES 146 146 N6-acetyllysine (By similarity).
 MOD_RES 196 196 Phosphotyrosine (By similarity).
 MOD_RES 199 199 N6-acetyllysine (By similarity).
 MOD_RES 203 203 Phosphoserine (By similarity).
 MOD_RES 267 267 N6-acetyllysine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).
 MOD_RES 390 390 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Glycolysis; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043531; F:ADP binding; IDA:RGD.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB.
 GO:0006094; P:gluconeogenesis; IDA:RGD.
 GO:0006096; P:glycolysis; IDA:RGD. 

Interpro

 IPR001576; Phosphoglycerate_kinase.
 IPR015901; Phosphoglycerate_kinase_C.
 IPR015911; Phosphoglycerate_kinase_CS.
 IPR015824; Phosphoglycerate_kinase_N. 

Pfam

 PF00162; PGK 

SMART

  

PROSITE

 PS00111; PGLYCERATE_KINASE 

PRINTS

 PR00477; PHGLYCKINASE.