CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Asparagine synthetase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
395SDGITSVKNSWFKILubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Asparagine biosynthesis; ATP-binding; Ligase; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MQQHFEFEYQ TKVDGEIILH LYDKGGIEQT ICMLDGVFAF VLLDTANKKV FLGRDTYGVR 60
PLFKAMTEDG FLAVCSEAKG LVTLKHSATP FLKVEPFLPG HYEVLDLKPN GKVASVEMVK 120
YHHCRDEPLH ALYDNVEKLF PGFEIETVKN NLRILFNNAV KKRLMTDRRI GCLLSGGLDS 180
SLVAATLLKQ LKEAQVQYPL QTFAIGMEDS PDLLAARKVA DHIGSEHYEV LFNSEEGIQA 240
LDEVIFSLET YDITTVRASV GMYLISKYIR KNTDSVVIFS GEGSDELTQG YIYFHKAPSP 300
EKAEEESERL LRELYLFDVL RADRTTAAHG LELRVPFLDH RFSSYYLSLP PEMRIPKNGI 360
EKHLLRETFE DSNLIPKEIL WRPKEAFSDG ITSVKNSWFK ILQEYVEHQV DDAMMANAAQ 420
KFPFNTPKTK EGYYYRQIFE RHYPGRADWL SHYWMPKWIN ATDPSARTLT HYKSAVKA 478 
Gene Ontology
 GO:0004066; F:asparagine synthase (glutamine-hydrolyzing) activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0070981; P:L-asparagine biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006426; Asn_synth_AEB.
 IPR001962; Asn_synthase.
 IPR017932; GATase_2_dom.
 IPR000583; GATase_dom.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00733; Asn_synthase
 PF13537; GATase_7 
SMART
  
PROSITE
 PS51278; GATASE_TYPE_2 
PRINTS