| Tag | Content |
|---|
| CPLM ID | CPLM-024411 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 8B |
Protein Synonyms/Alias | |
Gene Name | Tbc1d8b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 4 | ****MWLKPEEVLLK | ubiquitination | [1] | | 118 | ITNFVQGKIRGLIAE | ubiquitination | [1] | | 128 | GLIAEEGKQSFAKED | ubiquitination | [1] | | 375 | AFRFSELKDFEQLVA | ubiquitination | [1] | | 696 | LDKLLTCKDDAEAVT | ubiquitination | [1] | | 715 | FFDNVINKDSPLPSN | ubiquitination | [1] | | 733 | GSNISNEKSDHTKVD | ubiquitination | [1] | | 780 | QTLEETTKQNVLRVV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). |
Sequence Annotation | DOMAIN 145 212 GRAM 1.
DOMAIN 285 353 GRAM 2.
DOMAIN 486 673 Rab-GAP TBC.
DOMAIN 857 892 EF-hand. |
Keyword | Complete proteome; GTPase activation; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1114 AA |
Protein Sequence | MWLKPEEVLL KNALKLWLME RSNEYFVLQR RRGYGEEGGG GLTGLLVGTL DSVLDSTAKV 60
APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK TLSVFDSNED ITNFVQGKIR 120
GLIAEEGKQS FAKEDDPEKF REALLKFEKS FGLPEQEKLV TYYSCSYWRG RVPCQGWLYL 180
STNFLSFYSF LLGSEIKLII SWDAISKLEK TSTVILTESI HVCSQGENHY FSMFLHINET 240
YLLMEQLANY AIKRLFDKET FDNDPVLDDP LQITKRGLEY RAHSEQFKAF FRLPKEETLK 300
EVHECFLWVP FSHFSSHGKM CISENYICFA SQDGNLCSVI IPLREVLAID KTDDSNRSVI 360
ISIKGKTAFR FSELKDFEQL VAKLRLKCRA ASTQDDVSTE VAVSSDSTGP SENFEEQPLT 420
CPKECSKTVN TEALMTVFHP QNLENLDSKM LKEKMKEQSW NILFSECGRG VSMFRTKKTR 480
DLVVRGIPET LRGELWMLFS GAVNDMATNP GYYAEVVEQS LGTSNLATEE IERDLRRSLP 540
EHPAFQSDTG ISALRRVLTA YAYRNPKIGY CQAMNILTSV LLLYAKEEEA FWLLVAVCER 600
MLPDYFNRRI IGALVDQAVF EELIRDHLPQ LTDHMTDMTF FSSVSLSWFL TLFISVLPIE 660
SAVNVVDCFF YDGIKAILQL GLAILDYNLD KLLTCKDDAE AVTALNRFFD NVINKDSPLP 720
SNVQQGSNIS NEKSDHTKVD ITDLIKESNE KYGSIRYEDI HSMRCRNRLY VIQTLEETTK 780
QNVLRVVSQD VKMSLQELDE LYVIFKKELF ISCYWYLSCP GLKHHDPSLP YLEQYQIDCQ 840
QFRVLYHLLS PWAHSANRDS LALWTFRLLD ENSDCLINFK EFSSAIDIMY NGSFTDKLKL 900
LFKLHIPPAY TEVMSKTSSK GDELSTEELL YFSQLQVSKP ADEKETESGR NSPEKGKGKI 960
DIQAYLSQWQ DELLKKEETI KDLPRMNQSQ FIQFSKTLYN LFHEDPEEES LYQAIAIVTN 1020
LLLRMEEVGR KLHSPASSAS TARDSGPSEG NAESSVKKDL PSPREEHQWS FAFEQILASL 1080
LNEPALVRFF ERPLDLKAKL ENAKSSQLRS RTKM 1114 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |