CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029822
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Latrophilin-2 
Protein Synonyms/Alias
  
Gene Name
 LPHN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
341DNESETGKNSIDYIYubiquitination[1]
630QLSANTVKQNSRNGLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1384 AA 
Protein Sequence
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE 60
SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY 120
KYLEVQYECV PYMEQKVFVC PGTLKAIVDS PCIYEAEQKA GAWCKDPLQA ADKIYFMPWT 180
PYRTDTLIEY ASLEDFQNSR QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT 240
RIKSGEAIIN YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL 300
RFEATWETVY DKRAASNAFM ICGVLYVVRS VYQDNESETG KNSIDYIYNT RLNRGEYVDV 360
PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD PAQERFCEAL DSKGIKWPQT 420
QRGMMVERPC PKGTRGTASY LCMISTGTWN PKGPDLSNCT SHWVNQLAQK IRSGENAASL 480
ANELAKHTKG PVFAGDVSSS VRLMEQLVDI LDAQLQELKP SEKDSAGRSY NKAIVDTVDN 540
LLRPEALESW KHMNSSEQAH TATMLLDTLE EGAFVLADNL LEPTRVSMPT ENIVLEVAVL 600
STEGQIQDFK FPLGIKGAGS SIQLSANTVK QNSRNGLAKL VFIIYRSLGQ FLSTENATIK 660
LGADFIGRNS TIAVNSHVIS VSINKESSRV YLTDPVLFTL PHIDPDNYFN ANCSFWNYSE 720
RTMMGYWSTQ GCKLVDTNKT RTTCACSHLT NFAILMAHRE IAYKDGVHEL LLTVITWVGI 780
VISLVCLAIC IFTFCFFRGL QSDRNTIHKN LCINLFIAEF IFLIGIDKTK YAIACPIFAG 840
LLHFFFLAAF AWMCLEGVQL YLMLVEVFES EYSRKKYYYV AGYLFPATVV GVSAAIDYKS 900
YGTEKACWLH VDNYFIWSFI GPVTFIILLN IIFLVITLCK MVKHSNTLKP DSSRLENIKS 960
WVLGAFALLC LLGLTWSFGL LFINEETIVM AYLFTIFNAF QGVFIFIFHC ALQKKVRKEY 1020
GKCFRHSYCC GGLPTESPHS SVKASTTRTS ARYSSGTQSR IRRMWNDTVR KQSESSFISG 1080
DINSTSTLNQ GMTGNYLLTN PLLRPHGTNN PYNTLLAETV VCNAPSAPVF NSPGHSLNNA 1140
RDTSAMDTLP LNGNFNNSYS LHKGDYNDSV QVVDCGLSLN DTAFEKMIIS ELVHNNLRGS 1200
SKTHNLELTL PVKPVIGGSS SEDDAIVADA SSLMHSDNPG LELHHKELEA PLIPQRTHSL 1260
LYQPQKKVKS EGTDSYVSQL TAEAEDHLQS PNRDSLYTSM PNLRDSPYPE SSPDMEEDLS 1320
PSRRSENEDI YYKSMPNLGA GHQLQMCYQI SRGNSDGYII PINKEGCIPE GDVREGQMQL 1380
VTSL 1384 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. 
Interpro
 IPR022624; DUF3497.
 IPR017981; GPCR_2-like.
 IPR001879; GPCR_2_extracellular_dom.
 IPR003924; GPCR_2_latrophilin.
 IPR003334; GPCR_2_latrophilin_rcpt_C.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom.
 IPR000922; Lectin_gal-bd_dom.
 IPR003112; Olfac-like. 
Pfam
 PF00002; 7tm_2
 PF12003; DUF3497
 PF02140; Gal_Lectin
 PF01825; GPS
 PF02793; HRM
 PF02354; Latrophilin
 PF02191; OLF 
SMART
 SM00303; GPS
 SM00008; HormR
 SM00284; OLF 
PROSITE
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS
 PS51132; OLF
 PS50228; SUEL_LECTIN 
PRINTS
 PR00249; GPCRSECRETIN.
 PR01444; LATROPHILIN.