UniProt Accession

 HMOX1_HUMAN; P09601 

Genbank Protein ID

 X06985; CR456505; AY460337; Z82244; M23041; X14782 

Genbank Nucleotide ID

 CAA30045.1; CAG30391.1; AAR23262.1; CAB05109.1; AAA50403.1; CAA32886.1 

Protein Name

 Heme oxygenase 1 

Protein Synonyms/Alias

 HO-1 

Gene Name

 HMOX1 

Gene Synonyms/Alias

 HO; HO1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	QDLSEALKEATKEVH	acetylation	[1]
18	QDLSEALKEATKEVH	ubiquitination	[2]
39	EFMRNFQKGQVTRDG	acetylation	[3]
39	EFMRNFQKGQVTRDG	ubiquitination	[2]
69	EEEIERNKESPVFAP	ubiquitination	[2]
86	FPEELHRKAALEQDL	ubiquitination	[2, 4]
148	LSGGQVLKKIAQKAL	ubiquitination	[2, 4]
153	VLKKIAQKALDLPSS	ubiquitination	[2, 4]
177	PNIASATKFKQLYRS	ubiquitination	[2, 4]
179	IASATKFKQLYRSRM	ubiquitination	[2]
243	LRQRASNKVQDSAPV	ubiquitination	[2, 4, 5]
256	PVETPRGKPPLNTRS	ubiquitination	[2, 4]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. 

Sequence Annotation

 METAL 25 25 Iron (heme axial ligand).
 BINDING 18 18 Heme.
 BINDING 134 134 Heme.
 BINDING 183 183 Heme.
 MOD_RES 229 229 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005615; C:extracellular space; TAS:BHF-UCL.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; ISS:BHF-UCL.
 GO:0019899; F:enzyme binding; ISS:BHF-UCL.
 GO:0020037; F:heme binding; IDA:BHF-UCL.
 GO:0004392; F:heme oxygenase (decyclizing) activity; IMP:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004630; F:phospholipase D activity; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0001525; P:angiogenesis; TAS:BHF-UCL.
 GO:0008219; P:cell death; ISS:BHF-UCL.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0071276; P:cellular response to cadmium ion; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
 GO:0031670; P:cellular response to nutrient; IEA:Compara.
 GO:0001935; P:endothelial cell proliferation; TAS:BHF-UCL.
 GO:0034101; P:erythrocyte homeostasis; IMP:BHF-UCL.
 GO:0007588; P:excretion; IC:BHF-UCL.
 GO:0042167; P:heme catabolic process; IDA:BHF-UCL.
 GO:0006788; P:heme oxidation; IDA:BHF-UCL.
 GO:0007243; P:intracellular protein kinase cascade; TAS:BHF-UCL.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0034383; P:low-density lipoprotein particle clearance; TAS:BHF-UCL.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL.
 GO:0002686; P:negative regulation of leukocyte migration; TAS:BHF-UCL.
 GO:0032764; P:negative regulation of mast cell cytokine production; IEA:Compara.
 GO:0043305; P:negative regulation of mast cell degranulation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IDA:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0045080; P:positive regulation of chemokine biosynthetic process; TAS:BHF-UCL.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
 GO:0045909; P:positive regulation of vasodilation; IC:BHF-UCL.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0045765; P:regulation of angiogenesis; TAS:BHF-UCL.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; ISS:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; ISS:BHF-UCL.
 GO:0035094; P:response to nicotine; IDA:BHF-UCL.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0014806; P:smooth muscle hyperplasia; TAS:BHF-UCL.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0002246; P:wound healing involved in inflammatory response; IMP:BHF-UCL. 

Interpro

 IPR002051; Haem_Oase.
 IPR016053; Haem_Oase-like.
 IPR016084; Haem_Oase-like_multi-hlx.
 IPR018207; Haem_oxygenase_CS. 

Pfam

 PF01126; Heme_oxygenase 

SMART

  

PROSITE

 PS00593; HEME_OXYGENASE 

PRINTS

 PR00088; HAEMOXYGNASE.