UniProt Accession

 RB22A_HUMAN; Q9UL26; B3KR86; E1P605; Q8TF12; Q9H4E6 

Genbank Protein ID

 AF125104; AF091034; AJ276210; BT007046; AK091180; AL035455; CH471077; CH471077; BC015710; BC063457 

Genbank Nucleotide ID

 AAL75941.1; AAF00047.2; CAC10538.1; AAP35695.1; BAG52298.1; CAC15020.1; EAW75496.1; EAW75497.1; AAH15710.1; AAH63457.1 

Protein Name

 Ras-related protein Rab-22A 

Protein Synonyms/Alias

 Rab-22 

Gene Name

 RAB22A 

Gene Synonyms/Alias

 RAB22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	STLKNWVKELRQHGP	ubiquitination	[1]
181	PSGGKGFKLRRQPSE	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. 

Sequence Annotation

 NP_BIND 12 20 GTP (By similarity).
 NP_BIND 60 64 GTP (By similarity).
 NP_BIND 118 121 GTP (By similarity).
 NP_BIND 148 150 GTP (By similarity).
 MOTIF 34 42 Effector region (By similarity).
 LIPID 193 193 S-geranylgeranyl cysteine (By
 LIPID 194 194 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; Endosome; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; IDA:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:UniProtKB.
 GO:0006897; P:endocytosis; IDA:UniProtKB.
 GO:0007032; P:endosome organization; IEP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.